Title:Fresh Frozen Plasma Administration in the NICU: Evidence-based Guidelines
Volume: 19
Issue: 4
Author(s): Mario Motta*Brunetta Guaragni
Affiliation:
- Neonatology and Neonatal Intensive Care Unit, Children’s Hospital, Spedali Civili of Brescia, Brescia, Italy
Keywords:
Fresh frozen plasma, transfusion, neonatology, coagulation tests, bleeding, neonate.
Abstract: The use of FFP in neonatology should be primarily for neonates with active bleeding and
associated coagulopathy. However, since there is limited and poor-quality evidence supporting neonatal
FFP transfusion, considerable FFP usage continues to be outside of this recommendation, as
documented by neonatal transfusion audits. This review updates the scientific evidence available on
FFP use in neonatology and reports the best evidence-practice for the safety of neonates receiving
FFP.