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Research Article

与布鲁加达综合征相关的SCN5A突变蛋白理化性质的生物信息学见解

卷 30, 期 15, 2023

发表于: 30 December, 2022

页: [1776 - 1796] 页: 21

弟呕挨: 10.2174/0929867330666221130112650

价格: $65

摘要

背景：Brugada 综合征 (BrS) 是一种心律失常，通常与心源性猝死的强烈倾向有关。恶性室性心律失常可能继发于心脏钠电压门控 Na(v)1.5 信道 (SCN5A) 的功能障碍。 目的：本研究旨在使用一组生物信息学工具对与 BrS 相关的 SCN5A 突变体的理化特性进行多参数计算分析。 方法：校准内部算法以在双盲试验中计算每个串行的极性指数法 (PIM) 概况和蛋白质内在无序易感性 (PIDP) 概况，并使用专门用于基因组分析的计算机进程。 结果：SCN5A 突变蛋白的电荷/极性和 PIDP 配置文档中的特定规律使分类学的重新创建成为可能，使我们能够提出一种生物信息学方法，利用 PIM 配置文档从其串行中识别这组蛋白质。 结论：生物信息学进程可以再现 BrS 相关 SCN5A 突变蛋白的特征 PIM 和 PIDP 图谱。这些信息有助于更好地了解这些改变的蛋白质。

关键词: SCN5A，SCN5A基因，SNC5A突变蛋白，结构蛋白质组学，生物信息学，内在疾病易感性谱，极性指数方法谱。

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