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Review Article

心血管疾病中铁中毒靶向脂质过氧化的研究前景

卷 30, 期 31, 2023

发表于: 21 December, 2022

页: [3550 - 3561] 页: 12

弟呕挨: 10.2174/0929867330666221111162905

价格: $65

Open Access Journals Promotions 2
摘要

脂质代谢是调节正常细胞活性和死亡的复杂生化过程。铁死亡是一种新的程序性细胞死亡模式，不同于凋亡、焦亡和自噬。脂质代谢异常可导致脂质过氧化和细胞破裂死亡，脂质过氧化和细胞破裂死亡受脂氧合酶(LOX)、长链酰基辅酶a合成酶和抗氧化酶的调控。另外，LOXs和铁下垂的活性也需要Fe2+和Fe3+，并且Fe2+可以显著加速铁下垂的脂质过氧化。脂质代谢异常是心血管疾病的一定危险因素。近年来，关于铁下垂在心血管疾病发生中的重要作用的报道越来越多。减少脂质积累可减少铁下垂的发生，从而缓解心血管疾病的恶化。本文综述了脂质过氧化与铁下垂的一般机制的关系，并强调脂质过氧化是铁下垂和心血管疾病的共同点。

关键词: 脂质过氧化，脂质，心血管疾病，铁下垂，机制，脂氧化酶(LOX)。

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