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Review Article

Phytochemical and Pharmacological Aspects of Hygrophila Spinosa: An Overview

Author(s): Smruti Gaikwad, Lata Kothapalli* and Asha Thomas

Volume 1, 2023

Published on: 13 January, 2023

Article ID: e191022210155 Pages: 12

DOI: 10.2174/2210299X02666221019104843

open_access

Open Access Journals Promotions 2
Abstract

Background: A plant from the Acanthaceae family, Hygrophila spinosa T. Ander is geographically distributed throughout Asia and is noted for its diuretic and aphrodisiac properties in Ayurvedic literature. In the last four decades, various research teams have conducted experiments with the plant Hygrophila spinosa to screen the plant for hepatoprotective, anti-urolithiasis, diuretic, anti-hypertensive, anti-diabetic, chemoprotective, and anticancer activities along with analgesic and anti-inflammatory activity. Flavonoids, alkaloids, steroids, and triterpenoids are among the phytochemicals separated from different plant components, along with vitamins and minerals.

Objective: Considering the therapeutic value of the plant, focus on using current technology to quantify and confirm the pharmacological effects with in vitro and in vivo assays was felt and to shed light on in silico investigations.

Results: Relevant analytical tools for characterizing and quantifying phytoconstituents in the plant, along with emphasis on well-established pharmacological screening experiments on parts and whole plant extracts, commercially available formulations of H.spinosa have been elaborated. It has been discussed how to further validate the pharmacological effects using insilico methods and predictions from ADME/T analyses. H. spinosa based Phyto fabricated nanoparticle systems with gold and silver have broadened the use of plant extract as a metal. carrier which minimizesmetal. toxicity to further boost its synergistic effects in response to the growing need for targeted medicine delivery systems.

Conclusión: In light of the necessity to investigate a specific mechanism of action for each of the specific phytoconstituents contained in the plant, the present review summarizes the phytochemical and pharmacological importance of the plant in chronic illness.

Keywords: Hygrophila spinosa, Hepatoprotective, Reproductive activity, Antidiabetic, Antitumor, Phytochemicals.

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