Stem Cells: Therapeutic Implications in Chemotherapy and Radiotherapy
Resistance in Cancer Therapy

Tejaswini      Patil; Sonali   S.   Rohiwal; Arpita   P.   Tiwari
doi:10.2174/1574888X17666221003125208
Abstract

Cancer stem cells (CSCs) are transformed forms of normal stem cells within heterogeneous mixture of cancer cells. These are mainly responsible for the recurrence of cancer after treatment because of their ability to develop resistance against chemo and radiotherapy due to various factors such as activation of signalling pathways important for self-renewal, DNA repair capacity, microenvironment and expression of ABC transporters. Targeting these mechanisms as potential factors can eliminate CSCs, which eventually decreases cancer recurrence. This review focuses on the characteristics of CSCs, their role in the development of resistance to chemotherapy and radiotherapy along with the therapeutic potential targets for successful elimination of CSC population.
Keywords: Cancer stem cells, chemotherapy, radiotherapy, drug resistance, cancer therapy, biological agents.
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Graphical Abstract

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DOI https://dx.doi.org/10.2174/1574888X17666221003125208	Print ISSN 1574-888X
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Current Stem Cell Research & Therapy

Stem Cells: Therapeutic Implications in Chemotherapy and Radiotherapy Resistance in Cancer Therapy

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