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Review Article

白细胞免疫球蛋白样受体聚焦于B2亚家族的治疗意义

卷 23, 期 15, 2022

发表于: 21 September, 2022

页: [1430 - 1452] 页: 23

弟呕挨: 10.2174/1389450123666220822201605

价格: $65

摘要

白细胞免疫球蛋白(Ig)样受体(LILRs)由5个抑制亚群(LILRB1-5)和6个刺激亚群(LILRA1-6)组成。LILR群体主要存在于免疫细胞中，特别是髓系细胞，在免疫抑制和免疫刺激反应中起调节作用，在此过程中，非经典主要组织相容性复合体(MHC) I类分子广泛参与。此外，LILR也分布在某些肿瘤细胞中，与恶性肿瘤的进展有关。总的来说，到目前为止，抑制Ig样LILRB2的研究相对比较充分。本文综述了LILRs的整个家族及其与关键配体连接后在各种疾病中的生物学功能，从而为它们在这些病理过程中的潜在作用提供更多信息，并给出靶向LILR策略的临床意义。

关键词: 白细胞免疫球蛋白样受体，白细胞免疫球蛋白样受体B2, LILRs相关疾病，MHC-I，免疫治疗，癌症。

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