Title:Antihyperglycemic, Antihyperlipidemic, and Antioxidant Effects of Salvia
tingitana in Streptozotocin-Induced Diabetic Rats
Volume: 22
Issue: 2
Author(s): Amine Azzane and Mohamed Eddouks*
Affiliation:
- Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques, Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, Errachidia 52000, Morocco.
Keywords:
Diabetes mellitus, Salvia tingitana, lipid abnormalities, antihyperglycemic, antihyperlipidemic, phytochemical compounds.
Abstract:
Aims: The study aimed to assess the antidiabetic effect of Salvia tingitana (S. tingitana).
Background: S. tingitana is an aromatic plant that belongs to the Lamiaceae family. Phytochemical
analysis of the aerial parts of S. tingitana revealed the existence of terpenoids and flavonoids. In addition,
S. tingitana possesses antimicrobial activity.
Objective: The goal of the study was to obtain information about the antihyperglycemic, antihyperlipidemic,
antioxidant abilities of S. tingitana aqueous extract.
Methods: The effect of an acute and sub-chronic administration of S. tingitana aqueous extract
(AEST) at the doses of 60 and 80 mg/kg on glucose, lipid profile, and lipoprotein profile was examined
in normoglycemic and hyperglycemic rats. Additionally, a preliminary phytochemical screening
and the antioxidant activity using DPPH assay were carried out.
Results: Rats treated with AEST at a dose of 60 mg/kg showed a significant decrease in the serum
glucose levels during the single oral administration at the 4th and 6th hour of treatment in both normal
and streptozotocin(STZ)-induced hyperglycemic rats. Interestingly, a dose of 80 mg/kg AEST
produced a significant lowering effect on blood glucose levels at the 2nd, 4th, and 6th hour of treatment
after a single oral administration in both diabetic and normal rats. Both doses of AEST (60
and 80 mg/kg) revealed a significant amelioration of lipid and lipoprotein profile. In addition, the
qualitative and quantitative phytochemical analysis proved the presence of polyphenols compounds,
flavonoids, and tannins. Results suggest that S. tingitana contains some secondary metabolites like
alkaloids, phenols, flavonoids, and saponins. Importantly, the study revealed that the aqueous extract
of S. tingitana has a very interesting antioxidant activity (IC50 = 553.21 μg/ml).
Conclusion: The study illustrates the beneficial action of the aqueous extract of S. tingitana as an
antihyperglycemic and antihyperlipidemic agent.
