Title:Electrochemical Aptasensing for Lifestyle and Chronic Disease Management
Volume: 30
Issue: 8
Author(s): Sayali Upasham, Madhavi Pali, Badrinath Jagannath, Kai-Chun Lin and Shalini Prasad*
Affiliation:
- Department of Bioengineering, University of Texas at Dallas, Richardson, Texas-75080, USA
Keywords:
Electrochemical, aptasensor, biofluid, biosensor, biomarker, chronic diseases.
Abstract: Over the past decade, researchers have investigated electrochemical sensing
for the purpose of fabricating wearable point-of-use platforms. These wearable platforms
have the ability to non-invasively track biomarkers that are clinically relevant and provide
a comprehensive evaluation of the user’s health. Due to many significant operational
advantages, aptamer-based sensing is gaining traction.Aptamer-based sensors have
properties like long-term stability, resistance to denaturation, and high sensitivity. Using
electrochemical sensing with aptamer-based biorecognition is advantageous because it
provides significant benefits like lower detection limits, a wider range of operations, and,
most importantly, the ability to detect using a label-free approach. This paper provides an
outlook into the current state of electrochemical aptasensing. This review looks into the
significance of the detection of biomarkers like glucose, cortisol etc., for the purpose of
lifestyle and chronic disease monitoring. Moreover, this review will also provide a comprehensive
evaluation of the current challenges and prospects in this field.
