Title:Microwave-assisted Synthesis and Characterization of Acrylamide Grafted
Copolymer of Okra Gum with the Application of 32 Central Composite
Designs (CCD)
Volume: 20
Issue: 6
Author(s): Anshul Attri, Mohamad Taleuzzaman and Surajpal Verma*
Affiliation:
- Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Delhi Pharmaceutical
Sciences and Research University, Delhi, 110007, India
Keywords:
Grafted copolymer, acrylamide, okra gum, analytical technique, CCD, QbD.
Abstract:
Introduction: Modified polymeric materials are nowadays most commonly used for making
modified-release pharmaceutical dosage forms.
Methods: In this present research study, a grafted copolymer is synthesized by using acrylamide and okra
gum with the help of the redox initiator method. The method was optimized using a 3-factor, 2-level central
composite design (CCD). Optimization of the synthetic process was done by the application of QbD;
the amount of acrylamide (1-10g), amount of initiator (50-150 mg), and microwave irradiation exposure
time (1-5 min) were taken as critical process variables, and response factors were selected as percentage
grafting (% grafting) and percentage yield (% yield).
Results: The optimized formulation (F13) exhibited a maximum percentage of grafting of 82.2 and a
percentage yield of 12.54 of acrylamide (5.5g), amount of initiator as 100 mg, and microwave irradiation
exposure time as 3 min.
Conclusion: The characterization of synthesized grafted copolymer product was performed by using differential
scanning calorimetry (DSC), FT-IR spectroscopy, and scanning electron microscopy (SEM).
