Efficacy of Mesenchymal Stem Cells from Human Exfoliated Deciduous
Teeth and their Derivatives in Inflammatory Diseases Therapy

Junxiang      Su; Xuejun      Ge; Nan      Jiang; Ziqian      Zhang; Xiaowen      Wu
doi:10.2174/1574888X17666220417153309
Abstract

Mesenchymal stem cells derived from postnatal orofacial tissues can be readily isolated and possess diverse origins, for example, from surgically removed teeth or gingiva. These cells exhibit stem cell properties, strong potential for self-renewal, and show multi-lineage differentiation, and they have therefore been widely employed in stem cell therapy, tissue regeneration, and inflammatory diseases. Among them, stem cells from human exfoliated deciduous teeth [SHED] and their derivatives have manifested wide application in the treatment of diseases because of their outstanding advantages— including convenient access, easy storage, and less immune rejection. Numerous studies have shown that most diseases are closely associated with inflammation and that inflammatory diseases are extremely destructive, can lead to necrosis of organ parenchymal cells, and can deposit excessive extracellular matrix in the tissues. Inflammatory diseases are thus the principal causes of disability and death from many diseases worldwide. SHED and their derivatives not only exhibit the basic characteristics of stem cells but also exhibit some special properties of their own, particularly with regard to their great potential in inhibiting inflammation and tissue regeneration. SHED therapy may provide a new direction for the treatment of inflammation and corresponding tissue defects. In this review, we critically analyze and summarize the latest findings on the behaviors and functions of SHED, serum-free conditioned medium from SHED [SHED-CM], and extracellular vesicles, especially exosomes, from SHED [SHED-Exos], and discuss their roles and underlying mechanisms in the control of inflammatory diseases, thus further highlighting additional functions for SHED and their derivatives in future therapies.
Keywords: Stem cells from human exfoliated deciduous teeth [SHED], serum-free conditioned medium from SHED [SHEDCM], exosomes from SHED [SHED-Exos], inflammatory diseases, tissue regeneration, periodontal ligament stem cells [PDLSCs].
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Graphical Abstract

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DOI https://dx.doi.org/10.2174/1574888X17666220417153309	Print ISSN 1574-888X
Publisher Name Bentham Science Publisher	Online ISSN 2212-3946
Current Stem Cell Research & Therapy

Efficacy of Mesenchymal Stem Cells from Human Exfoliated Deciduous Teeth and their Derivatives in Inflammatory Diseases Therapy

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