Title:Safety Issues of Nanomaterials for Dermal Pharmaceutical Products
Volume: 10
Issue: 5
Author(s): Farzaneh Lotfipour, Shahriar Shahi, Khadijeh Khezri, Sara Salatin and Solmaz Maleki Dizaj*
Affiliation:
- Dental and Periodontal Research Center, Tabriz
University of Medical Sciences, Tabriz, Iran
Keywords:
Safety issues, nanomaterials, dermal pharmaceutical products, nano-medicine, nano-carrier.
Abstract: Nanomaterials (NMs) have favorable application in the medicine area, specifically in
regard to the carrying of pharmaceutical ingredients to provide targeted drug delivery systems. The
skin is an excellent route for the delivery of pharmaceutical nano-transporters for skin-related applications.
The physicochemical properties of nanomaterials such as size, hydrophobicity, loading
capacity, charge and weight are vital for a skin penetrating system. Many nanocarriers such as
polymeric nanoparticles, inorganic nanomaterials and, lipid nanostructures have been utilized for
dermal delivery of active ingredients and others such as carbon nanotubes and fullerenes require
more examination for future application in the skin-related area. Some negative side effects and
nano-cytotoxicity of nanomaterials require special attention while investigating different nanomaterials
for medicinal applications. Then, in the current review, we had a view on the safety issues
of nanomaterials for dermal pharmaceutical products.
