Generic placeholder image

Endocrine, Metabolic & Immune Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Review Article

Vaccine Efficacy Denial: A Growing Concern Affecting Modern Science, and Impacting Public Health

Author(s): Luca Signorini, Francesco Maria Ceruso, Elisabetta Aiello, Maria Josephine Zullo and Danila De Vito*

Volume 22, Issue 9, 2022

Published on: 08 June, 2022

Page: [935 - 943] Pages: 9

DOI: 10.2174/1871530322666220318092909

Price: $65

Open Access Journals Promotions 2
Abstract

The discovery of the vaccination technique was revealed by Edward Jenner in 1796, which represented the first scientific attempt to control an infectious disease by vaccines, followed by other important studies carried out by Pasteur and Koch, and Sabin, who developed the first technique to attenuate the virus. In recent decades, numerous scholars have begun to create dangerous theories against the effectiveness of vaccines through scientifically invalid or fraudulent studies.

This critical review of the literature aims to analyze the main factors that have undermined the credibility of vaccines in the general population, disproved false information and emphasized the benefits of vaccines over the last 200 years.

Unfortunately, several studies have been carried out without the proper scientific attention. The most impacting example is the study published by Andrew Wakefield in the Lancet journal who tried to correlate vaccines with the development of autism: this publication was withdrawn from the journal a few years after its publication, but the impact of incorrect scientific studies, fake news, and ambiguous healthcare policies have led to a general adverse opinion about the effectiveness of vaccines.

The excess of uncontrolled information is a serious concern during the Coronavirus pandemic. Modern science must tackle this problem with a better willingness to communicate the clinical studies to those who cannot understand medical information. Nevertheless, a reliable science must also limit the distribution of studies that do not meet the basic criteria of methodological rigor and certainty of results in order not to incur confusion in the scientific community.

Keywords: Preventive medicine, public health, history of medicine, vaccines, pandemic, preventive medicine, modern science.

Graphical Abstract
[1]
Hoenig, L.J.; Jackson, A.C.; Dickinson, G.M. The early use of Pasteur’s rabies vaccine in the United States. Vaccine, 2018, 36(30), 4578-4581.
[http://dx.doi.org/10.1016/j.vaccine.2018.05.016] [PMID: 29921493]
[2]
Miller, E.R.; Moro, P.L.; Cano, M.; Shimabukuro, T.T. Deaths following vaccination: What does the evidence show? Vaccine, 2015, 33(29), 3288-3292.
[http://dx.doi.org/10.1016/j.vaccine.2015.05.023] [PMID: 26004568]
[3]
Plotkin, S.A.; Plotkin, S.L. The development of vaccines: how the past led to the future. Nat. Rev. Microbiol., 2011, 9(12), 889-893.
[http://dx.doi.org/10.1038/nrmicro2668] [PMID: 21963800]
[4]
Ellis, H. James Phipps, first to be vaccinated against smallpox by Edward Jenner. J. Perioper. Pract., 2021, 31(1-2), 51-52.
[http://dx.doi.org/10.1177/1750458920950165] [PMID: 33251953]
[5]
Barkhordarian, A.; Thames, A.D.; Du, A.M.; Jan, A.L.; Nahcivan, M.; Nguyen, M.T.; Sama, N.; Chiappelli, F. Viral immune surveillance: Toward a TH17/TH9 gate to the central nervous system. Bioinformation, 2015, 11(1), 47-54.
[http://dx.doi.org/10.6026/97320630011047] [PMID: 25780281]
[6]
Tatullo, M.; Codispoti, B.; Paduano, F.; Nuzzolese, M.; Makeeva, I. Strategic tools in regenerative and translational dentistry. Int. J. Mol. Sci., 2019, 20(8), 1879.
[http://dx.doi.org/10.3390/ijms20081879] [PMID: 30995738]
[7]
Bressan, E.; Ferroni, L.; Gardin, C.; Bellin, G.; Sbricoli, L.; Sivolella, S.; Brunello, G.; Schwartz-Arad, D.; Mijiritsky, E.; Penarrocha, M.; Penarrocha, D.; Taccioli, C.; Tatullo, M.; Piattelli, A.; Zavan, B. Metal nanoparticles released from dental implant surfaces: Potential contribution to chronic inflammation and peri-implant bone loss. Materials (Basel), 2019, 12(12), 2036.
[http://dx.doi.org/10.3390/ma12122036] [PMID: 31242601]
[8]
Chiappelli, F.; Khakshooy, A.; Balenton, N. Clinical immunology of cholera - Current trends and directions for future advancement. Bioinformation, 2017, 13(10), 352-355.
[http://dx.doi.org/10.6026/97320630013352] [PMID: 29162969]
[9]
Gradmann, C. Robert Koch and the pressures of scientific research: Tuberculosis and tuberculin. Med. Hist., 2001, 45(1), 1-32.
[http://dx.doi.org/10.1017/S0025727300000028] [PMID: 11235050]
[10]
Barberis, I.; Bragazzi, N.L.; Galluzzo, L.; Martini, M. The history of tuberculosis: From the first historical records to the isolation of Koch’s bacillus. J. Prev. Med. Hyg., 2017, 58(1), E9-E12.
[PMID: 28515626]
[11]
Gamage, D.; Mach, O.; Ginige, S.; Weldon, W.C.; Oberste, M.S.; Jeyaseelan, V.; Sutter, R.W. Poliovirus type 2 seroprevalence following full- or fractional-dose inactivated poliovirus vaccine in the period after sabin type 2 withdrawal in Sri Lanka. J. Infect. Dis., 2019, 219(12), 1887-1892.
[http://dx.doi.org/10.1093/infdis/jiz026] [PMID: 30649505]
[12]
Romanò, L.; Paladini, S.; Galli, C.; Raimondo, G.; Pollicino, T.; Zanetti, A.R. Hepatitis B vaccination. Hum. Vaccin. Immunother., 2015, 11(1), 53-57.
[http://dx.doi.org/10.4161/hv.34306] [PMID: 25483515]
[13]
Johnson, N.F.; Velásquez, N.; Restrepo, N.J.; Leahy, R.; Gabriel, N.; El Oud, S.; Zheng, M.; Manrique, P.; Wuchty, S.; Lupu, Y. The online competition between pro- and anti-vaccination views. Nature, 2020, 582(7811), 230-233.
[http://dx.doi.org/10.1038/s41586-020-2281-1] [PMID: 32499650]
[14]
Codispoti, B.; Marrelli, M.; Paduano, F.; Tatullo, M. NANOmetric BIO-banked MSC-derived exosome (NANOBIOME) as a novel approach to regenerative medicine. J. Clin. Med., 2018, 7(10), 357.
[http://dx.doi.org/10.3390/jcm7100357] [PMID: 30326618]
[15]
Burki, T. The online anti-vaccine movement in the age of COVID-19. Lancet Digit. Health, 2020, 2(10), e504-e505.
[http://dx.doi.org/10.1016/S2589-7500(20)30227-2] [PMID: 32984795]
[16]
Xie, J.; He, Y. Ontology-based vaccine adverse event representation and analysis. Adv. Exp. Med. Biol., 2017, 1028, 89-103.
[http://dx.doi.org/10.1007/978-981-10-6041-0_6] [PMID: 29058218]
[17]
Stern, A.M.; Markel, H. The history of vaccines and immunization: Familiar patterns, new challenges. Health Aff. (Millwood), 2005, 24(3), 611-621.
[http://dx.doi.org/10.1377/hlthaff.24.3.611] [PMID: 15886151]
[18]
Taylor, L.E.; Swerdfeger, A.L.; Eslick, G.D. Vaccines are not associated with autism: An evidence-based meta-analysis of case-control and cohort studies. Vaccine, 2014, 32(29), 3623-3629.
[http://dx.doi.org/10.1016/j.vaccine.2014.04.085] [PMID: 24814559]
[19]
Marrelli, M.; Codispoti, B.; Shelton, R.M.; Scheven, B.A.; Cooper, P.R.; Tatullo, M.; Paduano, F. Dental pulp stem cell mechanoresponsiveness: Effects of mechanical stimuli on dental pulp stem cell behavior. Front. Physiol., 2018, 9, 1685.
[http://dx.doi.org/10.3389/fphys.2018.01685] [PMID: 30534086]
[20]
DeStefano, F. Vaccines and autism: Evidence does not support a causal association. Clin. Pharmacol. Ther., 2007, 82(6), 756-759.
[http://dx.doi.org/10.1038/sj.clpt.6100407] [PMID: 17928818]
[21]
Wakefield, A. A statement by Dr Andrew wakefield. Lancet, 2004, 363(9411), 823-824.
[http://dx.doi.org/10.1016/S0140-6736(04)15710-3] [PMID: 15022650]
[22]
Scerri, M.; Grech, V. Withdrawn: COVID-19, its novel vaccination and fake news - What a brew. Early Hum. Dev., 2020, 12, 105256.
[http://dx.doi.org/10.1016/j.earlhumdev.2020.105256] [PMID: 33221032]
[23]
van Prooijen, J.W.; Douglas, K.M. Belief in conspiracy theories: Basic principles of an emerging research domain. Eur. J. Soc. Psychol., 2018, 48(7), 897-908.
[http://dx.doi.org/10.1002/ejsp.2530] [PMID: 30555188]
[24]
Understanding the infodemic and misinformation in the fight against COVID-19. Department of evidence and intelligence for action in health office of the assistant director, 2020. Available from: www.paho.org/ish
[25]
Ballini, A.; Boccaccio, A.; Saini, R.; Van Pham, P.; Tatullo, M. Dental-derived stem cells and their secretome and interactions with bioscaffolds/biomaterials in regenerative medicine: From the in vitro research to translational applications. Stem Cells Int., 2017, 2017, 6975251.
[http://dx.doi.org/10.1155/2017/6975251] [PMID: 29445404]
[26]
Zarocostas, J. How to fight an infodemic. Lancet, 2020, 395(10225), 676.
[http://dx.doi.org/10.1016/S0140-6736(20)30461-X] [PMID: 32113495]
[27]
Vaccine confidence volatile, vulnerable to misinformation The Straits Times. 2020. Available from: https://www.straitstimes.com/ world/vaccine-confidence-volatile-vulnerable-to-misinformation
[28]
Inchingolo, F.; Tatullo, M.; Abenavoli, F.M.; Marrelli, M.; Inchingolo, A.D.; Inchingolo, A.M.; Dipalma, G. Non-Hodgkin lymphoma affecting the tongue: Unusual intra-oral location. Head Neck Oncol., 2011, 3(1), 1.
[http://dx.doi.org/10.1186/1758-3284-3-1] [PMID: 21205320]
[29]
Tatullo, M. Science is not a Social Opinion. Dent. J., 2019, 7(2), 34.
[http://dx.doi.org/10.3390/dj7020034] [PMID: 30939736]
[30]
MacDonald, N.E. Fake news and science denier attacks on vaccines. What can you do? Can. Commun. Dis. Rep., 2020, 46(1112), 432-435.
[http://dx.doi.org/10.14745/ccdr.v46i1112a11] [PMID: 33447164]
[31]
Elise, P.; Steptoe, A.; Fancourt, D. Attitudes towards vaccines and intention to vaccinate against COVID-19: Implications for public health communications. Lancet, 2020, 100012.
[32]
Bolcato, M.; Rodriguez, D.; Feola, A.; Di Mizio, G.; Bonsignore, A.; Ciliberti, R.; Tettamanti, C.; Trabucco Aurilio, M.; Aprile, A. COVID-19 Pandemic and equal access to vaccines. Vaccines (Basel), 2021, 9(6), 538.
[http://dx.doi.org/10.3390/vaccines9060538] [PMID: 34063863]
[33]
Sheikh, A.B.; Pal, S.; Javed, N.; Shekhar, R. COVID-19 Vaccination in developing nations: Challenges and opportunities for innovation. Infect. Dis. Rep., 2021, 13(2), 429-436.
[http://dx.doi.org/10.3390/idr13020041] [PMID: 34069242]
[34]
Dror, A.A.; Eisenbach, N.; Taiber, S.; Morozov, N.G.; Mizrachi, M.; Zigron, A.; Srouji, S.; Sela, E. Vaccine hesitancy: The next challenge in the fight against COVID-19. Eur. J. Epidemiol., 2020, 35(8), 775-779.
[http://dx.doi.org/10.1007/s10654-020-00671-y] [PMID: 32785815]
[35]
Cascini, F.; Pantovic, A.; Al-Ajlouni, Y.; Failla, G.; Ricciardi, W. Attitudes, acceptance and hesitancy among the general population worldwide to receive the COVID-19 vaccines and their contributing factors: A systematic review. E. Clini. Med., 2021, 40, 101113.
[http://dx.doi.org/10.1016/j.eclinm.2021.101113] [PMID: 34490416]
[36]
Aw, J.; Seng, J.J.B.; Seah, S.S.Y.; Low, L.L. COVID-19 Vaccine Hesitancy-A Scoping Review of Literature in High-Income Countries. Vaccines (Basel), 2021, 9(8), 900.
[http://dx.doi.org/10.3390/vaccines9080900] [PMID: 34452026]
[37]
Palamenghi, L.; Barello, S.; Boccia, S.; Graffigna, G. Mistrust in biomedical research and vaccine hesitancy: The forefront challenge in the battle against COVID-19 in Italy. Eur. J. Epidemiol., 2020, 35(8), 785-788.
[http://dx.doi.org/10.1007/s10654-020-00675-8] [PMID: 32808095]
[38]
Ferrera, G.; Squeri, R.; Genovese, C. The evolution of vaccines for early childhood: The MMRV. Ann. Ig., 2018, 30(4)(Suppl. 1), 33-37.
[PMID: 30062378]
[39]
Puri, N.; Coomes, E.A.; Haghbayan, H.; Gunaratne, K. Social media and vaccine hesitancy: New updates for the era of COVID-19 and globalized infectious diseases; Hum.Vaccines Immunother, 2020, pp. 1-8.
[40]
Daley, M.F.; Narwaney, K.J.; Shoup, J.A.; Wagner, N.M.; Glanz, J.M. Addressing parents’ vaccine concerns: A randomized trial of a social media intervention. Am. J. Prev. Med., 2018, 55(1), 44-54.
[http://dx.doi.org/10.1016/j.amepre.2018.04.010] [PMID: 29773490]
[41]
Ortiz-Sánchez, E.; Velando-Soriano, A.; Pradas-Hernández, L.; Vargas-Román, K.; Gómez-Urquiza, J.L.; Cañadas-De la Fuente, G.A.; Albendín-García, L. Analysis of the anti-vaccine movement in social networks: A systematic review. Int. J. Environ. Res. Public Health, 2020, 17(15), 5394.
[http://dx.doi.org/10.3390/ijerph17155394] [PMID: 32727024]
[42]
Betsch, C.; Renkewitz, F.; Betsch, T.; Ulshöfer, C. The influence of vaccine-critical websites on perceiving vaccination risks. J. Health Psychol., 2010, 15(3), 446-455.
[http://dx.doi.org/10.1177/1359105309353647] [PMID: 20348365]
[43]
Nan, X.; Madden, K. HPV vaccine information in the blogosphere: How positive and negative blogs influence vaccine-related risk perceptions, attitudes, and behavioral intentions. Health Commun., 2012, 27(8), 829-836.
[http://dx.doi.org/10.1080/10410236.2012.661348] [PMID: 22452582]
[44]
Basch, C.H.; Zybert, P.; Reeves, R.; Basch, C.E. What do popular YouTubeTM videos say about vaccines? Child Care Health Dev., 2017, 43(4), 499-503.
[http://dx.doi.org/10.1111/cch.12442] [PMID: 28105642]
[45]
Cinelli, M.; Quattrociocchi, W.; Galeazzi, A.; Valensise, C.M.; Brugnoli, E.; Schmidt, A.L.; Zola, P.; Zollo, F.; Scala, S. The COVID-19 social media infodemic. Sci. Rep., 2020, 10, 16598.
[46]
Dal-Ré, R.; Caplan, A.L. Current COVID-19 vaccine trials in high-income countries: Are placebo-controlled trials ethical? Clin. Microbiol. Infect., 2021, 11, 1565-1567.
[http://dx.doi.org/10.1016/j.cmi.2021.08.005]
[47]
Brunello, A.; Galiano, A.; Finotto, S.; Monfardini, S.; Colloca, G.; Balducci, L.; Zagonel, V. Older cancer patients and COVID-19 outbreak: Practical considerations and recommendations. Cancer Med., 2020, 9(24), 9193-9204.
[http://dx.doi.org/10.1002/cam4.3517] [PMID: 33219746]
[48]
Rutkowski, K.; Mirakian, R.; Till, S.; Rutkowski, R.; Wagner, A. Adverse reactions to COVID-19 vaccines: A practical approach. Clin. Exp. Allergy, 2021, 51(6), 770-777.
[http://dx.doi.org/10.1111/cea.13880] [PMID: 33813758]
[49]
Doherty, M.; Buchy, P.; Standaert, B.; Giaquinto, C.; Prado-Cohrs, D. Vaccine impact: Benefits for human health. Vaccine, 2016, 34(52), 6707-6714.
[http://dx.doi.org/10.1016/j.vaccine.2016.10.025] [PMID: 27773475]
[50]
European vaccination information portal. Available from: https://vaccination-info.eu/en/vaccine-facts/benefits-vaccinating (Accessed on May, 2020.).
[51]
I.R.C.C.S. Ospedale San Raffaele. Covid vaccines: why we need not fear long-term effects., 2021. Available from: https://www.hsr.it/news/2021/novembre/effetti-lungo-periodo-vaccino-covid-mrna (Accessed on November 5, 2021).
[52]
Chih-Cheng, L. I-Tzu, C.; Chien-Ming, C.; Ping-Ing, L.; Wen-Chien, K.; Po-Ren, H. COVID-19 vaccines: Concerns beyond protective efficacy and safety. Expert Rev. Vaccines, 2021, 20(8), 1013-1025.
[http://dx.doi.org/10.1080/14760584.2021.1949293]
[53]
Fenton, S.H.; Low, S.; Abrams, K.J.; Butler-Henderson, K. Health information management: Changing with time. Yearb. Med. Inform., 2017, 26(1), 72-77.
[http://dx.doi.org/10.15265/IY-2017-021] [PMID: 29063538]
[54]
Health information and quality authority. guidance on information governance for health and social care services in ireland [Internet]. Dublin: Health information and quality authority, 2012. Available from: https://www.hiqa.ie/sites/default/files/2017-01/Guidance-oninforma- tion-governance.pdf
[55]
Smallwood, R.F. Information governance: Concepts Strategies and Best Practices, 1st ed; Wiley: Hoboken, New Jersey, 2014, p. 442.
[56]
Shen, N.; Bernier, T.; Sequeira, L.; Strauss, J.; Silver, M.P.; Carter-Langford, A.; Wiljer, D. Understanding the patient privacy perspective on health information exchange: A systematic review. Int. J. Med. Inform., 2019, 125, 1-12.
[http://dx.doi.org/10.1016/j.ijmedinf.2019.01.014] [PMID: 30914173]
[57]
Kuo, T.T.; Kim, H.E.; Ohno-Machado, L. Blockchain distributed ledger technologies for biomedical and health care applications. J. Am. Med. Inform. Assoc., 2017, 24(6), 1211-1220.
[http://dx.doi.org/10.1093/jamia/ocx068] [PMID: 29016974]
[58]
Fusco, A.; Dicuonzo, G.; Dell’Atti, V.; Tatullo, M. Blockchain in healthcare: Insights on COVID-19. Int. J. Environ. Res. Public Health, 2020, 17(19), 7167.
[http://dx.doi.org/10.3390/ijerph17197167] [PMID: 33007951]
[59]
Angeles, R. Blockchain-based healthcare: Three successful proof-of-concept pilots worth considering. J. Inf. Technol. Manage., 2018, 27, 4.
[60]
Kayaalp, M. Patient privacy in the era of big data. Balkan Med. J., 2018, 35(1), 8-17.
[http://dx.doi.org/10.4274/balkanmedj.2017.0966] [PMID: 28903886]
[61]
Tatullo, M.; Spagnuolo, G.; Codispoti, B.; Zamparini, F.; Zhang, A.; Esposti, M.D.; Aparicio, C.; Rengo, C.; Nuzzolese, M.; Manzoli, L.; Fava, F.; Prati, C.; Fabbri, P.; Gandolfi, M.G. PLA-Based mineral-doped scaffolds seeded with human periapical cyst-derived MSCs: A promising tool for regenerative healing in dentistry. Materials (Basel), 2019, 12(4), 597.
[http://dx.doi.org/10.3390/ma12040597] [PMID: 30781537]
[62]
Tatullo, M.; Genovese, F.; Aiello, E.; Amantea, M.; Makeeva, I.; Zavan, B.; Rengo, S.; Fortunato, L. Phosphorene is the new graphene in biomedical applications. Materials (Basel), 2019, 12(14), 2301.
[http://dx.doi.org/10.3390/ma12142301] [PMID: 31323844]
[63]
Nguyen, D.C.; Ding, M.; Pathirana, P.N.; Seneviratne, A. Blockchain and AI-based solutions to combat coronavirus (COVID-19)-like epidemics: A survey. IEEE Access, 2021, 9, 95730-95753.
[64]
AGENAS - MeS Sant'Anna School of Advanced Studies: SSR resilience capacity - Focus 2020. Available from: https://www.agenas.gov.it/comunicazione/primo-piano/1926-diretta-resilienza-dei-ssr-focus-2020-9-luglio (Accessed on April 18, 2021).
[65]
Vecchio, S.; Fileti, L.; Reggi, A.; Moschini, C.; Lorenzetti, S.; Rubboli, A. Impatto della pandemia COVID-19 sui ricoveri per sindrome coronarica acuta: Revisione della letteratura ed esperienza monocentrica. G. Ital. Cardiol. (Rome), 2020, 21(7), 502-508.
[PMID: 32555565]
[66]
Metzler, B.; Siostrzonek, P.; Binder, R.K.; Bauer, A.; Reinstadler, S.J. Decline of acute coronary syndrome admissions in Austria since the outbreak of COVID-19: The pandemic response causes cardiac collateral damage. Eur. Heart J., 2020, 41(19), 1852-1853.
[http://dx.doi.org/10.1093/eurheartj/ehaa314] [PMID: 32297932]
[67]
Wong, B.; El-Jack, S.; Armstrong, G. Pandemic control: Getting to the heart of unintended consequences. N. Z. Med. J., 2020, 133(1520), 153-156.
[PMID: 32994610]
[68]
Osservatorio nazionale screening. Report on the delays accumulated by Italian screening programs following the Covid-19 pandemic. Second Report as at 30 September 2020. Available from: https://www.osservatorionazionalescreening.it/content/rapportosulla- ripartenza-degli-screening-settembre-2020
[69]
Scarano, A.; Inchingolo, F.; Murmura, G.; Traini, T.; Piattelli, A.; Lorusso, F. Three-dimensional architecture and mechanical properties of bovine bone mixed with autologous platelet liquid, blood, or physiological water: An in vitro study. Int. J. Mol. Sci., 2018, 19(4), 1230.
[http://dx.doi.org/10.3390/ijms19041230] [PMID: 29670035]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy