Title:Selected Phytochemicals to Combat Lungs Injury: Natural Care
Volume: 25
Issue: 14
Author(s): Rishita Dey, Asmita Samadder*Sisir Nandi*
Affiliation:
- Department of Zoology, Cytogenetics and Molecular Biology Lab., University of Kalyani, Kalyani, Nadia, 741235,
India
- Department of Pharmaceutical Chemistry, Global Institute of Pharmaceutical Education and Research (Affiliated
to Uttarakhand Technical University), Kashipur-244713, India
Keywords:
Natural care, phytoactive constituents, ARDS, pulmonary TB, lung cancer, and injury, tumor necrosis factor (TNF).
Abstract: The human has two lungs responsible for respiration and drug metabolism. Severe lung
infection caused by bacteria, mycobacteria, viruses, fungi, and parasites may lead to lungs injury.
Smoking and tobacco consumption may also produce lungs injury. Inflammatory and pain mediators
are secreted by alveolar macrophages. The inflammatory mediators, such as cytokines, interleukin
(IL)-1, IL-6, IL-8, IL-10, and tumor necrosis factor (TNF)-α, neutrophils, and fibroblasts are
accumulated in the alveoli sac, which becomes infected. It may lead to hypoxia followed by severe
pulmonary congestion and the death of the patient. There is an urgent need for the treatment of artificial
respiration and ventilation. However, the situation may be the worst for patients suffering
from lung cancer, pulmonary tuberculosis, and acute pneumonia caused by acute respiratory distress
syndrome (ARDS). Re-urgency has been happening in the case of coronavirus disease of
2019 (COVID-19) patients. Therefore, it is needed to protect the lungs with the intake of natural
phytomedicines. In the present review, several selected phyto components having the potential role
in lung injury therapy have been discussed. Regular intake of natural vegetables and fruits bearing
these constituents may save the lungs even in the dangerous attack of SARS-CoV-2 in lung cancer,
pulmonary TB, and pneumatic patients.
