Title:Black Phosphorous Aptamer-based Platform for Biomarker Detection
Volume: 30
Issue: 8
Author(s): Ajinkya Nene, Shengyong Geng, Wenhua Zhou*, Xue-Feng Yu, Hongrong Luo and Seeram Ramakrishna
Affiliation:
- Materials Interfaces Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences,
Shenzhen 518055, Guangdong, China
Keywords:
Black phosphorous, stability, cardiovascular disorders, bio-sensing, aptamer, biomarkers.
Abstract: Black phosphorus nanostructures (nano-BPs) mainly include BP nanosheets
(BP NSs), BP quantum dots (BPQDs), and other nano-BPs-based particles at nanoscale.
Firstly discovered in 2014, nano-BPs are one of the most popular nanomaterials. Different
synthesis methods are discussed in short to understand the basic concepts and developments
in synthesis. Exfoliated nano-BPs, i.e. nano-BPs possess high surface area, high
photothermal conversion efficacy, excellent biocompatibility, high charge carrier mobility
(~1000 cm-2V-1s-1), thermal conductivity of 86 Wm-1K-1; and these properties make it a
highly potential candidate for fabrication of biosensing platform. These properties enable
nano-BPs to be promising photothermal/drug delivery agents as well as in electrochemical
data storage devices and sensing devices; and in super capacitors, photodetectors, photovoltaics
and solar cells, LEDs, super-conductors, etc. Early diagnosis is very critical in
the health sector scenarios. This review attempts to highlight the attempts made towards
attaining stable BP, BP-aptamer conjugates for successful biosensing applications. BP-aptamer-
based platforms are reviewed to highlight the significance of BP in detecting biological
and physiological markers of cardiovascular diseases and cancer; to be useful in
disease diagnosis and management.