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Current Topics in Medicinal Chemistry

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ISSN (Online): 1873-4294

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Review Article

Recent Advances in the Design and Synthesis of Small Molecule Carbonic Anhydrase IX Inhibitors

Author(s): Pengcheng Lv*, Yinyi Cai, Jiayi Luo and Kun Chen*

Volume 22, Issue 7, 2022

Published on: 12 April, 2022

Page: [550 - 560] Pages: 11

DOI: 10.2174/1568026622666220215104312

Price: $65

Abstract

Human carbonic anhydrase (CA) IX is a tumor-associated protein since it is scarcely present in normal tissues but highly overexpressed in a large number of solid tumors, where it actively contributes to survival and metastatic spread of tumor cells. A variety of approaches and design strategies were reported that afford CA IX/XII specific inhibitors and avoid the compromising effects of isoforms-promiscuous compounds. CA IX inhibitors hybrids/conjugates have become an important scaffold to design therapeutic agents with both CA inhibition and anti-cancer effects. In this review, we firstly present an overview of the role of CA IX in hypoxic tumors physiopathology, then provide a comprehensive update on the rational design and synthesis of small molecule CA IX inhibitors discovered since 2019. Also, their structure-activity relationship analysis studies are covered. A brief description of applications for CA IX inhibition in other therapeutic areas is also provided.

Keywords: Carbonic anhydrases, pH regulation, CA IX inhibitors, Tumour hypoxia, Hypoxia inducible factor 1 (HIF1), Tumor- associated protein.

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Graphical Abstract

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