Title:Nanotechnological Advances in the Treatment of Epilepsy
Volume: 21
Issue: 10
Author(s): Ola Asem Mahmoud Abdou Ali, Mohd. Farooq Shaikh, M Saquib Hasnain, Farheen Sami, Abdullah Khan and Mohammed Tahir Ansari*
Affiliation:
- School of Pharmacy, University of Nottingham Malaysia, Jalan Broga, 43500-Semenyih, Malaysia
Keywords:
Epilepsy, liposomes, nanoparticles, blood brain barrier, metallic, resistance.
Abstract: Epilepsy is known as one of the major challenges for medical science. The sudden appearance
of a seizure has been a significant health emergency as it may lead to further complications.
Although key advancements have been achieved in terms of pharmacological approaches for
epilepsy, many issues remain uncertain. Lipid carriers have been at the forefront, especially in neurodegenerative
diseases, such as epilepsy, Alzheimer’s, dementia, etc. The blood-brain barrier still
appears to be a major impediment in the successful treatment of epileptic seizures. This is mainly
due to the limited bioavailability of most anti-convulsant drugs. The present review encompasses
the issues underlying the current approach for epilepsy drug treatment and highlights the newer,
novel, and more precise drug delivery system to manage seizures. The advantage of using a lipidbased
delivery system is its superior absorption in the brain cells. Ample evidence shows that reducing
the particle size also infuses the drug easily through the blood-brain barrier. The application of
liposomes, polymeric nanoparticles, metallic nanoparticles, and solid lipid nanoparticles for the
treatment and management of epilepsy has been highlighted in the present review. This review provides
an overview of the current status of the treatment and recent advances in the treatment of
epilepsy.
