Title:Research Update on the Pathophysiological Mechanisms of Heart
Failure with Preserved Ejection Fraction
Volume: 23
Issue: 1
Author(s): Yuying Zhou, Yunlong Zhu and Jianping Zeng*
Affiliation:
- Department of Cardiology, Xiangtan Central Hospital, Xiangtan 411100, China
Keywords:
Heart failure, diastolic dysfunction, inflammation and oxidative stress, endothelial dysfunction, chronotropic incompetence, cardiac reserve dysfunction, pulmonary hypertension.
Abstract: Heart failure (HF) is a serious clinical syndrome, usually occurs at the
advanced stage of various cardiovascular diseases, featured by high mortality and
rehospitalization rate. According to left ventricular (LV) ejection fraction (LVEF), HF has
been categorized as HF with reduced EF (HFrEF; LVEF<40%), HF with mid-range EF
(HFmrEF; LVEF 40-49%), and HF with preserved EF (HFpEF; LVEF ≥50%). HFpEF
accounts for about 50% of cases of heart failure and has become the dominant form of
heart failure. The mortality of HFpEF is similar to that of HFrEF. There are no welldocumented
treatment options that can reduce the morbidity and mortality of HFpEF
now. Understanding the underlying pathological mechanisms is essential for the
development of novel effective therapy options for HFpEF. In recent years, significant
research progress has been achieved on the pathophysiological mechanism of HFpEF.
This review aimed to update the research progress on the pathophysiological mechanism
of HFpEF.
