Title:Therapeutic Targeting of Inflammatory Pathways with Emphasis on
NLRP3 Inflammasomes by Natural Products: A Novel Approach for
the Treatment of Inflammatory Eye Diseases
Volume: 29
Issue: 16
Author(s): Amro M. Soliman*, Ru Hui Sim, Srijit Das*Pasuk Mahakkanukrauh
Affiliation:
- Department of Biological Sciences—Physiology, Cell and Developmental Biology, University of Alberta,
Edmonton, AB T6G 2R3, Canada
- Department of
Human & Clinical Anatomy, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Sultanate
of Oman
Keywords:
Inflammation, eye diseases, NLRP3 inflammasome, treatment, natural products, BRB.
Abstract: There is an increase in the incidence of inflammatory eye diseases worldwide.
Several dysregulated inflammatory pathways, including the NOD-like receptor protein 3
(NLRP3) inflammasome, have been reported to contribute significantly to the pathogenesis
and progression of ophthalmic diseases. Although the available allopathic/ conventional
medicine has demonstrated effectiveness in managing eye diseases, there is an ongoing
global demand for alternative therapeutics with minimal adverse drug reactions,
easy availability, increase in patient compliance, and better disease outcomes. Therefore,
several studies are investigating the utilization of natural products and herbal formulations
in impeding inflammatory pathways, including the NLRP3 inflammasome, in order to
prevent or manage eye diseases. In the present review, we highlight the recently reported
inflammatory pathways with special emphasis on NLRP3 Inflammasomes involved in the
development of eye diseases. Furthermore, we present a variety of natural products and
phytochemicals that were reported to interfere with these pathways and their underlying
mechanisms of action. These natural products represent potential therapeutic applications
for the treatment of several inflammatory eye diseases.
