Title:Review of the Phytochemistry and Biological Activity of Cissus incisa Leaves
Volume: 21
Issue: 26
Author(s): Deyani Nocedo-Mena*, Adrián Alejandro Galván-Rodrigo, Colin W. Wright and Pierluigi Caboni*
Affiliation:
- Faculty of Physic-Mathematical Sciences, Autonomous University of Nuevo León, 66451, San Nicolss de los Garza, Nuevo Leon,Mexico
- Dipartamento Scienze della vita e dell’ambiente, Universita degli Studi di Cagliari, Cittadella Universitaria, Monserrato, C.P. 09042, Cagliari,Italy
Keywords:
Cissus incisa, Vitaceae, Antimicrobial, Cytotoxic, Modeling, Molecular docking, Biophysical assay.
Abstract:
Background: Cissus incisa is a Vitaceae with a pantropical distribution. In northern
Mexico, its leaves have traditionally been used to treat skin infections, abscesses and tumors. Despite
its medicinal uses, few studies have been reported.
Objective: The objective of this study is to summarize the phytochemical and biological studies carried
out so far on the leaves of C. incisa, since this part of the plant is the one frequently used, and
awaken scientific interest towards the plant.
Methods: Since C. incisa was an undocumented species, most of the information comes from reports
of our research group. Databases, books, and websites were also consulted. The information
collected was organized and presented in a synthesized way. Plant name was checked with the
database “The Plant List”.
Results: 171, 260, and 114 metabolites were identified by UHPLC-QFTOF-MS in the hexane, chloroform/
methanol, and aqueous extracts, respectively. Fatty acyls, sphingolipids, sterols,
glycerolipids, prenol lipids, and terpenes are common metabolites found in these extracts. 2-(2´-hydroxydecanoyl
amino)-1,3,4-hexadecanotriol-8-ene, 2,3-dihydroxypropyl tetracosanoate, β-sitosterol,
β-sitosterol-D-glucopyranoside, α-amyrin-3-O-β-D-glucopyranoside were also isolated and
characterized. Extracts, phytocompounds and semi-synthetic derivatives showed antimicrobial activity
against multi-drug resistant bacteria and various cancer cell lines. Results from Perturbation-
Theory-Machine Learning-Information-Fusion model (PTMLIF), molecular docking, and
vesicular contents assay identified potential targets on the cell membrane, suggesting an antibacterial
mechanism of action for ceramides from C. incisa leaves.
Conclusion: This review reports the efforts of the scientific community in authenticating species
used in traditional medicine. Moreover, it gives a compendium of phytochemistry and the biological
activities of the components from C. incisa leaves.
