Title:High-Frequency Oscillations and Epileptogenic Network
Volume: 20
Issue: 9
Author(s): Xiaonan Li, Herui Zhang, Huanling Lai, Jiaoyang Wang, Wei Wang and Xiaofeng Yang*
Affiliation:
- Bioland Laboratory, Guangzhou, China
- Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry
of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing,
China
Keywords:
High-frequency oscillations, HFO network, epileptogenic network, biomarker in epilepsy, epileptogenic zone, surgery.
Abstract: Epilepsy is a network disease caused by aberrant neocortical large-scale connectivity
spanning regions on the scale of several centimeters. High-frequency oscillations, characterized by
the 80-600 Hz signals in electroencephalography, have been proven to be a promising biomarker of
epilepsy that can be used in assessing the severity and susceptibility of epilepsy as well as the location
of the epileptogenic zone. However, the presence of a high-frequency oscillation network remains
a topic of debate as high-frequency oscillations have been previously thought to be incapable
of propagation, and the relationship between high-frequency oscillations and the epileptogenic network
has rarely been discussed. Some recent studies reported that high-frequency oscillations may
behave like networks that are closely relevant to the epileptogenic network. Pathological highfrequency
oscillations are network-driven phenomena and elucidate epileptogenic network development;
high-frequency oscillations show different characteristics coincident with the epileptogenic
network dynamics, and cross-frequency coupling between high-frequency oscillations and other
signals may mediate the generation and propagation of abnormal discharges across the network.
