Title:Pluripotent Stem Cells for Livestock Health and Production
Volume: 17
Issue: 3
Author(s): Meeti Punetha, Kamlesh K. Bajwa, Seema Dua, Sonu Bansal, Vineichuno Kuotsu, Atul Parashar, Naresh L. Selokar, Pradeep Kumar, P.S. Yadav and Dharmendra Kumar*
Affiliation:
- Animal Physiology and Reproduction Division, ICAR-Central Institute for Research on Buffaloes, Hisar-125001, Haryana, India
Keywords:
Cellular reprogramming, livestock, pluripotency, stem cells, iPS cells, health, production., stem cells (PSCs).
Abstract: Pluripotent stem cells (PSCs) have unlimited capacity for self-renewal and differentiation
so that they can potentially produce any cell or tissue of animal’s body. The PSCs derived
from livestock represents a more appropriate model than a rodent for investigating human diseases
due to their higher anatomical and physiological resemblance with human. Apart from that, livestock
PSCs hold immense promises for innovative therapies, transgenic animal production and their
biomedical interest. The realization of the full potential of PSCs, however, depends on the elucidation
of the molecular mechanisms which play a critical role in the maintenance of pluripotency and
reprogramming procedure remains poorly understood in livestock which in turn impedes the generation
of true PSCs and their usage for clinical research. An in-depth understanding of pluripotency
is extremely essential for improving health and welfare of livestock animals. Therefore, the present
review focuses on the milestone achievements of PSCs in livestock animals and their potential application
in health and production of livestock.
