Title:Association Between miR-146a rs2910164 Polymorphism and Breast Cancer
Susceptibility: An Updated Meta-Analysis of 9545 Cases and 10030
Controls
Volume: 10
Issue: 3
Author(s): Abdolkarim Moazeni-Roodi, Sajjad Aftabi, Sahel Sarabandi, Shima Karami, Mohammad Hashemi*, Saeid Ghavami*Mohsen Taheri*
Affiliation:
- Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan,Iran
- Genetics of
Non-communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
- Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg,Canada
- Research Institute
in Oncology and Hematology, CancerCare Manitoba, University of Manitoba, Winnipeg, Canada
- Genetics of Non-communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan,Iran
- Department of
Genetic, School of Medicine, Zahedan University of Medical Sciences, Zahed an, Iran
Keywords:
Breast cancer, meta-analysis, mir-146a, polymorphism, odd ratios, single nucleotide polymorphisms (SNPs
Abstract:
Background: Several studies have reported a possible association of miR-146a
rs2910164 polymorphism with Breast Cancer (BC) development. However, the correlation between
this polymorphism and susceptibility to BC is under debate. The current meta-analysis was
designed and performed to more conclusively evaluate the miR-146a rs2910164 polymorphism
and its potential link to BC.
Methods: Our team has selected eligible studies (published up to October 2, 2020) from several
electronic databases, including Web of Science, PubMed, Scopus and Google Scholar. A total number
of 9,545 BC cases and 10,030 controls extracted from 26 eligible articles were included in this
study. We utilized pooled Odds Ratios (ORs) as well as 95% confidence intervals (95% CIs) under
five genetic models for quantitative estimation of any possible association between miR-146a
rs2910164 polymorphism and BC.
Results: Based on this meta-analysis, our findings suggest that there is no significant association
between miR-146a rs2910164 polymorphism and BC risk. However, stratified analysis revealed
that the rs2910164 polymorphism significantly increased the risk of BC in hospital-based studies
using the homozygous genetic model (OR=1.37, 95%CI=1.01-1.86, p=0.043, CC vs. GG). Neither
Asian nor Caucasian populations showed any significant association between rs2910164 polymorphism
and BC susceptibility.
Conclusion: In summary, our findings suggest that BC development is not associated with
miR-146a rs2910164 polymorphism. However, larger ingenious future investigations might be
needed for a more precise estimation of any association between miR-146a rs2910164 polymorphism
and BC.
