Title:Role of Natural Bioactives and their Nanocarriers for Overcoming Oxidative Stress Induced Cancer
Volume: 28
Issue: 36
Author(s): Saurabh Mittal, Muhammad Usama Ashhar, Alka Ahuja, Javed Ali and Sanjula Baboota*
Affiliation:
- Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062,India
Keywords:
Oxidative stress, reactive oxygen species, cancer, nanoformulations, natural bioactives, nanocarriers.
Abstract:
Background: Oxidative stress and free radicals are harmful to human health. Reactive
oxygen species are the major source of oxidative stress and are one of the major causes
of cancer development. Cancer is one of the leading causes of death worldwide. Prolonged
use of synthetic chemotherapeutic due to their low bioavailability leads to systemic
toxic side effects. To surmount this problem, the use of antioxidants is recommended as they
have the ability to counteract oxidative stress and mitigate its effects on human health. They
inhibit various pathways that are involved with the initiation and progression of cancer. Various
nanoformulations have been used to deliver these antioxidants (curcumin, mangiferin,
quercetin) in the treatment of various cancer for overcoming oxidative stress.
Objective: The main focus of this review article is to illustrate various studies performed
using nanocarriers of natural bioactives to overcome oxidative stress and cancer associated
with it. It also describes pathways associated with the induction, initiation and progression
of cancer due to reactive oxidative species.
Methods: Research articles that focused on the use of natural bioactives and their nanoformulations
for the treatment of various cancers induced due to oxidative stress, were collected
from various search engines like PubMed, Science Direct and Google Scholar, using
keywords like oxidative stress, antioxidants, cancers, ROS, etc.
Conclusion: Natural bioactives have shown great potential in overcoming oxidative stress for
the treatment of various cancers. However, extensive research is required so that these antioxidants
and their nanocarriers can be used for the welfare of mankind, in the treatment of various
cancers, in the near future.
