Title:Relationship between Gentamicin Administration and Ductal Patency in
Very Low Birth Weight Infants
Volume: 17
Issue: 2
Author(s): Ufuk Cakir*Cuneyt Tayman
Affiliation:
- Division of Neonatology, Department of Pediatrics, Health Sciences University, Ankara Bilkent City Hospital,
Ankara, Turkey
Keywords:
Gentamicin, hemodynamically significant patent ductus arteriosus, premature, very low birth weight, neonatal intensive care unit, ductus arteriosus.
Abstract:
Background: Patent Ductus Arteriosus (PDA) is associated with adverse clinical outcomes
in very low birth weight (<1500g) infants.
Objective: In our study, it was aimed to investigate the effect of gentamicin treatment, which is frequently
used for early-onset sepsis on ductal patency.
Methods: We performed a single-center retrospective review of charts of preterm infants <32
weeks gestation with birth weight <1500 grams born between June 1, 2015 and December 31, 2019
at the neonatal intensive care unit. All infants underwent an echocardiogram (ECHO) at 72 hours.
To determine the effect of gentamicin treatment on hemodynamically significant PDA (hsPDA),
we compared the frequency and duration of gentamicin administration between infants with hsPDA
and without hsPDA.
Results: During the study period, 792 patients were evaluated. Gentamicin was given to more infants
with hsPDA than to those without hsPDA (89.2% vs. 64.6%, p<0.001), and the duration of
therapy was longer in those infants with hsPDA (7 days vs. 9 days, p<0.001). The area under the
curve for duration of gentamicin was 0.772 (%95 CI: 0.742-0.804, P=0.0001), sensitivity: 59 (%95
CI: 53-65), specificity: 82 (%95 CI: 78-88), with a cut-off day for duration of gentamicin >7 days.
Conclusion: In our study, it was found that ductal contraction decreased and hsPDA rate increased
as the rate and duration of gentamicin increased.
