Title:Magic Shotgun Nature with Scattergun Approach of Curcumin Repurposing in Obsessive-compulsive Disorder: A Novel Metaphysician of Drug Discovery
Volume: 20
Issue: 10
Author(s): Rahul Kumar Mishra *, Ashutosh Mishra and Amresh Gupta
Affiliation:
- Department of Pharmacology, Faculty of Pharmacy, Institute of Technology and Management GIDA Gorakhpur (Dr. A P J Abdul Kalam Technical University Lucknow), U.P,India
Keywords:
Magic shotgun, magic pills, scattergun, repurposing, Curcuma longa, OCD, marble-burying behaviour, multifarious
receptors.
Abstract:
Background: Obsessive-Compulsive Disorder (OCD) is an intricate, debilitating neuropsychiatric
disorder. Exclusively, Selective Serotonin Reuptake Inhibitors (SSRIs) are effective
agents used for the treatment of OCD. However, SSRIs are not a magic pill-they do not respond adequately
to everybody. In this consideration, a single drug target (magic bullet) is only a slightly superior
option for all patients with a lot of pathognomonic signs.
Objective: The principal aim of the current study was to check the potential contribution of repurposing
of magic shotgun nature of curcumin (rhizomes of Curcuma longa) with scattergun approach-
proceeding a pioneer ‘fine-tune’ for obsessive-compulsive disorder.
Method: Swiss albino mice (male 20 to 25 gram) were grouped into different groups (n = 6) used
for the MBB (marble-burying behaviour) and MA (motor activity) test as a model for evaluation of
anti-compulsive activity (Anti-OCD). Ethanolic extract of Curcuma longa (EECL-10, 15, 25, 40
mg/kg), or SSRI (fluoxetine 5, 10, 15 mg/kg) followed by pre-treated with either sub effective dose
of fluoxetine attenuated MBB without effected the MA, or neurotoxin p-chlorophenyl alanine induced
compulsive behavior and specific 5-HT receptors agonists/ antagonist, intraperitoneally revealed
neuromodulation.
Results: EECL (40 mg/kg) significantly attenuated the MBB. Although, during treatments, none of
the above had any critical impact on MA. p < 0.05 was considered significant in every case.
Conclusion: Multiple drug-target interactions with multifarious biogenic receptors, supervene unexpected
side effects followed by the repurposing of wanted effects (scattergun effect) were
evoked by curcumin treatment. Finally, the study shows that EECL (curcumin) has anti-compulsive
activity, which is mediated by neuromodulation with 5-HT receptors.
