Title:Anti-aging Natural Compounds and their Role in the Regulation of Metabolic Pathways Leading to Longevity
Volume: 21
Issue: 18
Author(s): Aqsa Muzammil, Muhammad Waqas, Ahitsham Umar, Muhammad Sufyan, Abdur Rehman, Ali Haider, Haseeb Akram, Seemab Amjad Fateh Khan, Muhammad Afzal, Muhammad Wajid, Rana Adnan Tahir and Sheikh Arslan Sehgal*
Affiliation:
- Department of Bioinformatics, University of Okara, Okara,Pakistan
Keywords:
Aging, natural products, drug designing, Alzheimer's disease, signaling pathways, pro-longevity drugs.
Abstract: Aging is an unavoidable process, leading to cell senescence due to physiochemical changes
in an organism. Anti-aging remedies have always been of great interest since ancient times. The purpose
of anti-aging activities is to increase the life span and the quality of life. Anti-aging activities are
primarily involved in the therapies of age-related disorders such as Parkinson's Disease (PD), Alzheimer's
Disease (AD), cardiovascular diseases, cancer, and chronic obstructive pulmonary diseases. These
diseases are triggered by multiple factors that are involved in numerous molecular pathways including
telomere shortening, NF-κB pathway, adiponectin receptor pathway, insulin, and IGF signaling
pathway, AMPK, mTOR, and mitochondria dysfunction. Natural products are known as effective molecules
to delay the aging process through influencing metabolic pathways and thus ensure an extended
lifespan. These natural compounds are being utilized in drug design and development through computational
and high throughput techniques for effective pro-longevity drugs. A comprehensive study on
natural compounds demonstrating their anti-aging activities along with databases of natural products
for drug designing was executed and summarized in this review article.
