Title:The Main Receptors Involved in the COVID-19: A Systematic Review and Meta-Analysis
Volume: 28
Issue: 34
Author(s): Alice Barros Câmara*Igor Augusto Brandão
Affiliation:
- Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal,Brazil
Keywords:
Brain, COVID-19, epidermal growth factor receptor, G protein-coupled receptor, inflammation, plasmareceptors.
Abstract:
Objective: This review aims to study the receptor's family and functions most
related to COVID-19 infection and also suggest the tissue and cell location on which the
majority of COVID-19 receptors are mainly expressed.
Methods: This systematic review is according to PRISMA guidelines. PubMed,
Cochrane, SciELO, Lilacs, Web of Science, and DOAJ databases were used. Clinical
trials and research articles studying receptors related to COVID-19 were included in this
review. R programming language was used to elaborate charts and receptors network,
and SPSS(26v) software was used to perform statistical analysis (PROSPERO:
CRD42020210643).
Results: The majority of studies on the involvement of receptors in COVID-19 included
plasma receptors and G protein-coupled receptor families (p<0.05). These receptors are
highly expressed in the brain (24%) and 80% of them can interact with each other in a
protein network, exerting some regulatory effects on various tissues. The main influential
receptor in the network of receptors involved in the COVID-19 was the EGFR and the
majority of receptors were associated with pathological processes of the disease
(p<0.05), including the amplification of inflammatory responses in COVID-19, which
may be related to neurological disorders in some cases. Studies on receptors involved in
the COVID-19 included mainly patients from the United States, Spain, and Brazil
(p<0.05).
Conclusion: Plasma receptors and G protein-coupled receptors, especially the EGFR, involved
in pathological effects of the COVID-19 inflammatory process in the brain have
shown significant importance in this review.
