Title:Impact of Curcumin on Microsomal Enzyme Activities: Drug Interaction and Chemopreventive Studies
Volume: 28
Issue: 34
Author(s): Habibeh Mashayekhi-Sardoo, Adeleh Mashayekhi-Sardoo, Basil D. Roufogalis, Tannaz Jamialahmadi and Amirhossein Sahebkar*
Affiliation:
- Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad,Iran
Keywords:
Herb-drug interaction, pharmacokinetics, phase I metabolism, microsomal enzymes, CYP enzymes,
curcumin.
Abstract: Curcumin, a yellow pigment in Asian spice, is a natural polyphenol component
of Curcuma longa rhizome. Curcuminoid components include curcumin,
demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC). Previous studies
established curcumin as a safe agent based on preclinical and clinical evaluations and curcuminoids
have been approved by the US Food and Drug Administration (FDA) as “Generally
Recognized as Safe” (GRAS). The present review collects and summarizes clinical
and preclinical studies of curcumin interactions, with an emphasis on the effect of curcumin
and curcumin analogs on the mRNA and protein levels of microsomal CYP450 enzymes
(phase I metabolism) and their interactions with toxicants, drugs and drug probes.
The literature search was conducted using keywords in various scientific databases, including
Web of Science, Scopus, PubMed, and Google Scholar. Studies concerning the
impact of curcumin and curcumin analogs on microsomal enzyme activity are reviewed
and include oral, topical, and systemic treatment in humans and experimental animals, as
well as studies from in vitro research. When taken together, the data identified some inconsistent
results between various studies. The findings showed significant inhibition of
CYP450 enzymes by curcumin and its analogs. However, such effects are often differed
when curcumin and curcumin analogs were coadministered with toxicant and other drugs
and drug probes. We conclude from this review that herb-drug interactions should be considered
when curcumin and curcumin analogs are consumed.
