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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Review Article

Liposomes as Versatile Platform for Cancer Theranostics: Therapy, Bio-imaging, and Toxicological Aspects

Author(s): Swapnil Mehta, Sanjay Kulkarni, Ajinkya N. Nikam, Bharat S. Padya, Abhijeet Pandey and Srinivas Mutalik*

Volume 27, Issue 17, 2021

Published on: 11 March, 2021

Page: [1977 - 1991] Pages: 15

DOI: 10.2174/1381612827666210311142100

Price: $65

Abstract

Liposomes are nano-sized formulations having the benefits of site-specificity, biocompatibility, and biodegradability, which make them useful for the therapy and diagnosis of major diseases like cancer. In this review, various synthetic strategies of liposomes and their biomedical application in special concern to cancer are discussed. In context to the biomedical application, this article gives a detailed insight into subcellular targeted therapy and several therapeutic modifications like immunotherapy, receptor-based therapy, phototherapy, and combination therapy. The review also describes the liposome-based imaging platforms and the toxicity associated with liposomes. Owing to a significant amount of benefits of this carrier system, several products have been approved to be launched in the market and several others have already been marketed for clinical use.

Keywords: Liposomes, site-specificity, cancer therapy, imaging platform, toxicity, toxicological aspects.

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