Title:A Review on Anti-urease Potential of Coumarins
Volume: 22
Issue: 17
Author(s): Humna Asghar*, Hafsa Asghar and Tanzeela Asghar
Affiliation:
- Department of Biochemistry and Biotechnology, Faculty of Science, The Islamia University of Bahawalpur, Bahawalpur,Pakistan
Keywords:
Synthetic coumarins, natural coumarins, drug discovery, jack bean urease, H. pylori, SAR.
Abstract: Coumarins, a heterocyclic benzo-α-pyrones and naturally occurring ring structure that
possess significant pharmacological properties, have attracted the attention of researchers and
medicinal chemists to reveal the suitability of both natural and synthetic coumarins as drugs. Many
compounds have been synthesized utilizing the basic coumarin structure. The diverse synthetic
methods resulted in the synthesis of important coumarin derivatives that offer a wide range of biological
properties as antimicrobial, anticancer, anti-inflammatory, antioxidant, antidiabetic and antidepressant
that make them potential drug candidates. With a particular interest in ulcers, coumarins
have shown potential inhibition against urease enzyme. In recent years, scientists have emphasized
the anti-urease activity of coumarins due to their low toxicity. The aim of this review is to
compile data from recent research about anti-urease activities of coumarins and structure-activity
relationship studies of the coumarin ring structure. Investigation of different structural substitutions
in coumarin rings may help researchers to design new compounds with strong and effective anti-
urease abilities.
