Title:Prospective Role of Polyphenolic Compounds in the Treatment of Neurodegenerative Diseases
Volume: 20
Issue: 5
Author(s): Rokeya Akter, Habibur Rahman*, Tapan Behl, Mohammad Arifur Rahman Chowdhury, Mohammad Manirujjaman, Israt Jahan Bulbul, Shimaa E. Elshenaw, Delia Mirela Tit and Simona Bungau
Affiliation:
- Department of Pharmacy, Southeast University, Banani 42130, Dhaka-1213,Bangladesh
Keywords:
Neurodegeneration, polyphenols, inflammation, reactive oxygen species, AD, PD.
Abstract: Aging is an important stage of the human life cycle and the primary risk factor for Neurodegenerative
Diseases (ND). The aging process contributes to modifications in cells, which may
lead to a lack of nutrient signaling, disrupted cellular activity, increased oxidative pressure, cell
homeostasis depletion, genomic instability, misfolded protein aggregation, impaired cellular protection,
and telomere reduction. The neuropathologies found in Alzheimer's Disease (AD) and Parkinson's
Disease (PD) are internally and extrinsically compound environmental stressors which may
be partially alleviated by using different phytochemicals. The new therapies for ND are restricted
as they are primarily targeted at final disease progression, including behavioral shifts, neurological
disorders, proteinopathies and neuronal failure. This review presents the role of phytochemicals-related
polyphenolic compounds as an accompanying therapy model to avoid neuropathologies
linked to AD, PD and to simultaneously enhance two stochastic stressors, namely inflammation
and oxidative stress, promoting their disease pathologies. Therefore, this approach represents a prophylactic
way to target risk factors that rely on their action against ND that does not occur through
current pharmacological agents over the life of a person.
