Title:Progress on Precise Regulation of Vascular Intimal Repair by a Surface Coating of Vascular Stent
Volume: 18
Issue: 7
Author(s): Shihui Liu , Junchao Zhi, Shijie Li, Zhuoyue Song, Tao Gong , Changjiang Pan, Chunzhi Tang, Nenggui Xu*Tao Liu*
Affiliation:
- Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006,China
- Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006,China
Keywords:
Stent, surface modification, gene delivery, restenosis, endothelialization, precision medicine.
Abstract: In the past few decades, drug-eluting stents have made significant contributions to the
treatment of coronary heart disease. However, due to the delayed healing of endothelial injuries
caused by antiproliferative drugs and insufficient biocompatibility of vascular stent materials, late
in-stent thrombosis and restenosis remain major challenges. Surface modification of cardiovascular
materials to construct a biological functional layer that can regulate the behavior of blood and vascular
cells is an effective way to improve the clinical performance of vascular stents. This paper reviewed
the common methods of surface bio-functional modification of cardiovascular materials
and especially proposed that take advantage of the new concept of precision medicine, as well as
the precise and orderly regulation properties of cardiovascular disease-related gene fragments on
vascular biological response behavior, the construction of gene-eluting stents which can in-situ regulate
vascular intimal repair at the molecular and genetic level will become an important research
direction in the future.
