Title:A Mini Review on Emerging Targets and Approaches for the Synthesis of Anti-viral Compounds: In Perspective to COVID-19
Volume: 21
Issue: 10
Author(s): Maheswara Rao Gokada, Visweswara Rao Pasupuleti* Hari Babu Bollikolla*
Affiliation:
- Department of Biomedical Sciences & Therapeutics, Faculty of Medicine and Health Sciences, University Malaysia Sabah, 88400, Kota Kinabalu Sabah,Malaysia
- Department of Chemistry, Acharya Nagarjuna University, N Nagar, Guntur-522510, AP,India
Keywords:
Coronavirus, hydroxychloroquine, remedisvir, favipiravir, mechanism of action, COVID-19.
Abstract: The novel Coronavirus disease (COVID-19) is an epidemic disease that appeared at the end
of the year 2019 with a sudden increase in number and came to be considered as a pandemic disease
caused by a viral infection which has threatened most countries for an emergency search for new
anti-SARS-COV drugs /vaccines. At present, the number of clinical trials is ongoing worldwide on
different drugs i.e. Hydroxychloroquine, Remedisvir, Favipiravir that utilize various mechanisms of
action. A few countries are currently processing clinical trials, which may result in a positive outcome.
Favipiravir (FPV) represents one of the feasible treatment options for COVID-19, if the result
of the trials turns out positive. Favipiravir will be one of the developed possibly authoritative drugs
to warrant benefits to mankind with large-scale production to meet the demands of the current pandemic
Covid-19 outbreak and future epidemic outbreaks. In this review, the authors tried to explore
key molecules, which will be supportive for devising COVID-19 research.