Title:An Insight Into Mitochondrial Dysfunction and its Implications in Neurological Diseases
Volume: 22
Issue: 14
Author(s): Rashid Waseem, Anas Shamsi, Syed N. Kazim and Asimul Islam*
Affiliation:
- Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi,India
Keywords:
Alzheimer's disease, mitochondrial homeostasis, apoptosis, oxidative stress, mitochondrial dysfunction, amyotrophic
lateral sclerosis.
Abstract: In the last few years, a massive increase in research has been observed that focuses on investigating
the role of mitochondria in the pathogenesis of several neurodegenerative disorders. Mitochondria
are vital cell organelles having important roles in different cellular processes, including
energy production, calcium signaling, Reactive Oxygen Species (ROS) generation, apoptosis, etc.
Therefore, healthy mitochondria are necessary for cell survival and functioning. It would seem feasible
that mitochondrial dysfunction will have implications in various pathological conditions. A
large body of evidence indicates the role of the mitochondrion as a potential key player in the loss
or dysfunction of neurons in various neurodegenerative disorders. In this review, we provide an insight
into mitochondrial dysfunction and its involvement in the pathology of several neurological
diseases such as Alzheimer’s disease, Parkinson’s disease, Amyotrophic Lateral Sclerosis, Hypoxic-
Ischemic Brain Injury, and many more.
