Title:Targeting the JAK/STAT Signaling Pathway for Breast Cancer
Volume: 28
Issue: 25
Author(s): Fei Shao, Xiaonan Pang and Gyeong Hun Baeg*
Affiliation:
- Ciechanover Institute of Precision and Regenerative Medicine, School of Life and Health Sciences, Chinese University of Hong Kong, Shenzhen, Guangdong 518172,China
Keywords:
Breast cancer, JAK/STAT pathway, inhibitors, targeted therapy, therapeutics, STAT3 dimerization.
Abstract: Breast cancer is the most common malignant tumor in women worldwide. Traditional
ways of treatment, including radiotherapy and endocrine therapy, for breast cancer
have inevitable side effects. In recent decades, targeted therapies for breast cancer
have rapidly advanced and shown a promising future. The JAK/STAT signaling pathway
has been shown to play important roles in tumorigenesis, maintenance and metastasis of
breast cancer. Hence, many small molecule inhibitors of JAK and STAT proteins have
been developed. These inhibitors exhibit potent inhibitory effects on breast cancer in
both cellular and animal models, and even some of them have already been in clinical
trials. This review article discussed the JAK/STAT signal transduction pathway in the
pathogenesis of breast cancer, and the potential for the application of JAK/STAT inhibitors
in breast cancer treatment.
