Title:Targeting the Nucleotide Metabolism Proteins of the NUDIX Family and SAMHD1 in Cancer
Volume: 28
Issue: 21
Author(s): Prescillia Forey, Emeline Cros-Perrial, Charles Dumontet and Lars Petter Jordheim*
Affiliation:
- Univ Lyon, Universite Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Leon Berard, Centre de Recherche en Cancerologie de Lyon, Lyon, 69008,France
Keywords:
NUDIX, MTH1, SAMHD1, cancer, treatment, inhibitors.
Abstract: Nucleotide metabolism has been targeted for many years and in various clinical
settings, including cancer. The increased knowledge of certain enzymes involved in
this metabolism and associated cellular processes accumulated over the last few years,
gives important information related to the druggability of certain proteins and the use of
inhibitors for others. Here, we review recent data on such enzymes with a major interest
in drug development, i.e. SAMHD1 and the proteins of the NUDIX family. These include
information on their roles in cancer progression, correlations with clinical outcomes
in cancer patients, and the development and study of enzymatic inhibitors.
