Title:Structure-Activity Relationship of Supramolecular Compounds in Drug Delivery
Volume: 18
Issue: 7
Author(s): P. Rajalakshmi, Daniel N. Peter, Jesu Johnson S. and Nallamuthu Ananthi*
Affiliation:
- Department of Chemistry, Karunya Institute of Technology and Sciences, Coimbatore -641114, Tamil Nadu,India
Keywords:
Supramolecular compounds, drug delivery, structure activity relationship, cyclodextrin, cucurbituril, avidin, biotin,
rotaxane, viologen, dendrimer.
Abstract: Supramolecular compounds are capable of undergoing various non-covalent interactions
with other molecules like host-guest chemistry, controlled encapsulation, hydrophobic interactions, a
variety of delivering strategies, electron affinity induced interactions, etc. These properties of supramolecular
compounds make them attractive to be effective drug carriers. This review will describe in
detail the recent interesting reports on the structure-activity relationship of supramolecular compounds
in drug delivery. The supramolecular compounds considered are cyclodextrins, cucurbiturils,
avidin, biotin, rotaxanes, viologens, and dendrimers. Studying the opportunities given by these supramolecular
compounds in drug delivery will pave the way for novel efficient drug delivery systems
for the future.
