Title:Pre- and Post-Conditioning of the Heart: An Overview of Cardioprotective Signaling Pathways
Volume: 19
Issue: 5
Author(s): Denise Coutinho de Miranda*, Gabriela de Oliveira Faria*, Milla Marques Hermidorff, Fernanda Cacilda dos Santos Silva, Leonardo Vinícius Monteiro de Assis and Mauro César Isoldi
Affiliation:
- Laboratory of Cell Signaling, Research Center in Biological Science, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto,Brazil
- Laboratory of Cell Signaling, Research Center in Biological Science, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto,Brazil
Keywords:
Heart, ischemic pre-conditioning, ischemic post-conditioning, pre-pharmacological conditioning, postpharmacological
conditioning, remote pre-conditioning, cardioprotective signaling pathway, cardioprotective drugs.
Abstract: Since the discovery of ischemic pre- and post-conditioning, more than 30 years ago, the
knowledge about the mechanisms and signaling pathways involved in these processes has significantly
increased. In clinical practice, on the other hand, such advancement has yet to be seen. This article provides
an overview of ischemic pre-, post-, remote, and pharmacological conditioning related to the
heart. In addition, we reviewed the cardioprotective signaling pathways and therapeutic agents involved
in the above-mentioned processes, aiming to provide a comprehensive evaluation of the advancements
in the field. The advancements made over the last decades cannot be ignored and with the exponential
growth in techniques and applications. The future of pre- and post-conditioning is promising.
