Title:Application of 3D Printing Technology in Bone Tissue Engineering: A Review
Volume: 18
Issue: 7
Author(s): Yashan Feng*, Shijie Zhu, Di Mei, Jiang Li, Jiaxiang Zhang, Shaolong Yang and Shaokang Guan*
Affiliation:
- Biomechanical Engineering Laboratory, Zhengzhou Railway Vocational and Technical College, Zhengzhou,China
- School of Materials Science and Engineering, Zhengzhou University, Zhengzhou,China
Keywords:
3D printing, tissue engineering, biomaterial, metal, bio-ceramics, biodegradable, porosity.
Abstract: Clinically, the treatment of bone defects remains a significant challenge, as it requires autogenous
bone grafts or bone graft substitutes. However, the existing biomaterials often fail to meet
the clinical requirements in terms of structural support, bone induction, and controllable biodegradability.
In the treatment of bone defects, 3D porous scaffolds have attracted much attention in the
orthopedic field. In terms of appearance and microstructure, complex bone scaffolds created by 3D
printing technology are similar to human bone. On this basis, the combination of active substances,
including cells and growth factors, is more conducive to bone tissue reconstruction, which is of
great significance for the personalized treatment of bone defects. With the continuous development
of 3D printing technology, it has been widely used in bone defect repair as well as diagnosis and rehabilitation,
creating an emerging industry with excellent market potential. Meanwhile, the diverse
combination of 3D printing technology with multi-disciplinary fields, such as tissue engineering,
digital medicine, and materials science, has made 3D printing products with good biocompatibility,
excellent osteoinductive capacity, and stable mechanical properties. In the clinical application of
the repair of bone defects, various biological materials and 3D printing methods have emerged to
make patient-specific bioactive scaffolds. The microstructure of 3D printed scaffolds can meet the
complex needs of bone defect repair and support the personalized treatment of patients. Some of
the new materials and technologies that emerged from the 3D printing industry's advent in the past
decade successfully translated into clinical practice. In this article, we first introduced the development
and application of different types of materials that were used in 3D bioprinting, including metal,
ceramic materials, polymer materials, composite materials, and cell tissue. The combined application
of 3D bioprinting and other manufacturing methods used for bone tissue engineering are also
discussed in this article. Finally, we discussed the bottleneck of 3D bioprinting technique and
forecasted its research orientation and prospect.
