Title:Application of Contemporary Neuroproteomic Techniques in Unravelling Neurological Disorders
Volume: 21
Issue: 12
Author(s): Mallika Khurana, Syed Obaidur Rahman, Abul Kalam Najmi, Faheem Hyder Pottoo and Md Sayeed Akhtar*
Affiliation:
- Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha,Saudi Arabia
Keywords:
Neuroproteomic Techniques, neurological Disorders, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis,
epilepsy, psychiatric disorders, Omics.
Abstract: Decades of research has stunned us with the very distinctive anatomy and physiology of
our brain, and on the other hand, its complexity has always posed great difficulty in treating its dysfunction
or damage. Understanding the brain under normal and, particularly in the diseased state,
has always been very challenging and would have been impossible without proteomics. Neuroproteomic
techniques have been extensively used for unraveling both dynamics and content of the proteome
of our nervous system. This modern-day investigation and quantification of protein concentration
and expression have given us a platform that enhances our knowledge on disease-associated
processes and pathways modification and also leads to the identification of possible biomarkers
that can be therapeutically targeted. With an increased interest in identifying and targeting possible
biomarkers, this article focuses on describing applications of the much discussed neuroproteomics,
with a significant role in the disease pathogenesis of some very common neurological disorders.
This article will collectively discuss the use and relevance of neuroproteomics in a range of neurological
diseases, such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, epilepsy, and
psychiatric disorders. We have also attempted to present the current successes and failures of the
neuroproteomics approach on the results obtained from different clinical studies that targeted biomarkers
associated with any particular neurological disorder.
