Login Register Cart 0
Generic placeholder image

Current Nanomedicine

Editor-in-Chief

ISSN (Print): 2468-1873
ISSN (Online): 2468-1881

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Lipid-based Nano-phytomedicines for Disease Treatment and Theranostic Applications

Author(s): Faraat Ali*, Shaik Khasimbi and Asad Ali

Volume 11, Issue 1, 2021

Published on: 23 October, 2020

Page: [40 - 50] Pages: 11

DOI: 10.2174/2468187310999201023151700

Price: $65

Open Access Journals Promotions 2
Abstract

Several lipid-based nanophytomedicines for illustrations, solid lipid nanoparticles, nanocomposites, lipid carriers, phytosomes, cubosomes, nanoemulsions, microcapsules, ethosomes, etc., are exploited to enhance the efficacy and safety of various bioactive phytochemicals with respect to their delivery to therapeutic target sites. Less lipid solubility, week stability, complex moiety, and inadequate metabolism in the gut are approximate of the serious problems of phytomedicine that have been emphasized extremely. In addition, these help design therapeutically efficacious and active nanophytomedicines. Disease diagnosis and compound imaging have also become important applications of nano-phytomedicine now. The aim of this review is to provide the current progress of lipid-based nanophytomedicines for the treatment of various life-threatening diseases and their theranostic applications.

Keywords: Nanophytomedicines, bioactive phytochemicals, theranostic, efficacy, Lipids, Neurological disorders.

« Previous Next »
Graphical Abstract

[1]
Zhu S, Luo C, Feng W, et al. Selenium-deposited tripterine phytosomes ameliorate the antiarthritic efficacy of the phytomedicine via a synergistic sensitization. Int J Pharm 2020; 57: 8119104.
[http://dx.doi.org/10.1016/j.ijpharm.2020.119104] [PMID: 32018017]
[2]
Balusamy SR, Veerapan K, Rajan A, et al. Phyllanthus emblica fruit extract attenuates lipid metabolism in 3T3-L1 adipocytes via activating apoptosis mediated cell death. Phytomed 2019; 66: 153129.
[3]
Ali OM, Bekhit AA, Khattab SN, et al. Synthesis of lactoferrin mesoporous silica nanoparticles for pemetrexed/ellagic acid synergistic breast cancer therapy. Colloids Surf B Biointerfaces 2020; 188: 110824.
[http://dx.doi.org/10.1016/j.colsurfb.2020.110824] [PMID: 32023511]
[4]
Nagaraju GP, Srivani G, Dariya B, et al. Nanoparticles guided drug delivery and imaging in gastric cancer. Semin Cancer Biol 2021; 69: 69-76.
[http://dx.doi.org/10.1016/j.semcancer.2020.01.006] [PMID: 31954835]
[5]
Fernando IPS, Ryu B, Ahn G, Yeo I-K, Jeon Y-J. Therapeutic potential of algal natural products against metabolic syndrome: A review of recent developments. Trends Food Sci Technol 2020; 97: 286-99.
[http://dx.doi.org/10.1016/j.tifs.2020.01.020]
[6]
Xu Y, Wang D, Zhang Y, et al. A novel electrochemical sensor for determination of hydroxyl radicals in living cells by coupling nanoporous gold layer with self-assembled 6-(Ferrocenyl) hexanethiol. Analy Chim Acta 2020; 1096: 69-75.
[7]
Nazar S, Hussain MA, Khan A, Muhammad G, Tahir MN. Capparis decidua Edgew (Forssk): A comprehensive review of its traditional uses, phytochemistry, pharmacology and nutrapharmaceutical potential. Arab Jr Chem 2020; 13: 1901-16.
[8]
Ling L, Lu Y, Zhang Y, et al. Flavonoids from Houttuynia cordata attenuate H1N1-induced acute lung injury in mice via inhibition of influenza virus and Toll-like receptor signalling. Phytomed 2019; 153150.
[9]
Zhang S, Zhu P, He J, et al. TME-Responsive Polyprodrug Micelles for Multistage Delivery of Doxorubicin with Improved Cancer Therapeutic Efficacy in Rodents. Adv Healthc Mater 2020; 9(18): e2000387.
[http://dx.doi.org/10.1002/adhm.202000387] [PMID: 32815646]
[10]
Chuang SY, Lin CH, Huang TH, Fang JY. Lipid-based nanoparticles as a potential delivery approach in the treatment of rheumatoid arthritis. Nanomaterials (Basel) 2018; 8(1): 42.
[http://dx.doi.org/10.3390/nano8010042]
[11]
Nian K, Shah MA, Khan F, Saleem U, Vargas C, Panichayupakaranant P. Bioavailability and safety of phytonutrients. Phytonutr Food 2020; 117-36.
[12]
Mulet X, Boyd BJ, Drummond CJ. Advances in drug delivery and medical imaging using colloidal lyotropic liquid crystalline dispersions. J Colloid Interface Sci 2013; 393: 1-20.
[http://dx.doi.org/10.1016/j.jcis.2012.10.014] [PMID: 23237762]
[13]
Liang XJ, Chen C, Zhao Y, Wang PC. Circumventing tumor resistance to chemotherapy by nanotechnology. Methods Mol Biol 2010; 596: 467-88.
[http://dx.doi.org/10.1007/978-1-60761-416-6_21] [PMID: 19949937]
[14]
Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 2003; 3(10): 768-80.
[http://dx.doi.org/10.1038/nrc1189] [PMID: 14570043]
[15]
Basnet P, Skalko-Basnet N. Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment. Molecules 2011; 16(6): 4567-98.
[http://dx.doi.org/10.3390/molecules16064567] [PMID: 21642934]
[16]
Liu RH. Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr 2003; 78(3)(Suppl.): 517S-20S.
[http://dx.doi.org/10.1093/ajcn/78.3.517S] [PMID: 12936943]
[17]
Wang S, Su R, Nie S, et al. Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals. J Nutr Biochem 2014; 25(4): 363-76.
[http://dx.doi.org/10.1016/j.jnutbio.2013.10.002] [PMID: 24406273]
[18]
Park S-H, Oh S-G, Mun J-Y, Han S-S. Loading of gold nanoparticles inside the DPPC bilayers of liposome and their effects on membrane fluidities. Colloids Surf B Biointerfaces 2006; 48(2): 112-8.
[http://dx.doi.org/10.1016/j.colsurfb.2006.01.006] [PMID: 16520025]
[19]
He X, Li Q, Liu X, Wu G, Zhai G. Curcumin-Loaded Lipid Cubic Liquid Crystalline Nanoparticles: Preparation, Optimization, Physicochemical Properties and Oral Absorption. J Nanosci Nanotechnol 2015; 15(8): 5559-65.
[http://dx.doi.org/10.1166/jnn.2015.10311] [PMID: 26369117]
[20]
Yucel C, Quagliariello V, Iaffaioli RV, Ferrari G, Donsì F. Submicron complex lipid carriers for curcumin delivery to intestinal epithelial cells: Effect of different emulsifiers on bioaccessibility and cell uptake. Int J Pharm 2015; 494(1): 357-69.
[http://dx.doi.org/10.1016/j.ijpharm.2015.08.039] [PMID: 26291881]
[21]
Linkevičiūtė A, Misiūnas A, Naujalis E, Barauskas J. Preparation and characterization of quercetin-loaded lipid liquid crystalline systems. Colloids Surf B Biointerfaces 2015; 128: 296-303.
[http://dx.doi.org/10.1016/j.colsurfb.2015.02.001] [PMID: 25701115]
[22]
Beutler JA. Natural Products as a foundation for drug discovery. Curr Protocols Pharmacol 2009; 46(1): 1-21.
[http://dx.doi.org/10.1002/0471141755.ph0911s46] [PMID: 20161632]
[23]
Bonifacio BV, da Silva PB, dos Santos Ramos MA, Negri KMS, Bauab TM, Chorilli M. Nanotechnology-based drug delivery system and herbal medicines: a review.In J Nanomed. 2014; 9: pp. 1-15.
[24]
Martinho N, Damge C. Reis Cp, Recent advances in drug delivery system. J Biomater Nanobiotechnol 2011; 2: 510.
[http://dx.doi.org/10.4236/jbnb.2011.225062]
[25]
Razzacki SZ, Thwar PK, Yang M, Ugaz VM, Burns MA. Integrated microsystems for controlled drug delivery. Adv Drug Deliv Rev 2004; 56(2): 185-98.
[http://dx.doi.org/10.1016/j.addr.2003.08.012] [PMID: 14741115]
[26]
Liu Z, Tabakman S, Welsher K, Dai H. Carbon nanotubes in biology and medicine: in vitro and in vivo detection, imaging and drug delivery. Nano Res 2009; 2(2): 85-120.
[http://dx.doi.org/10.1007/s12274-009-9009-8] [PMID: 20174481]
[27]
Umar A, Dunn BK, Greenwald P. Future directions in cancer prevention. Nat Rev Cancer 2012; 12(12): 835-48.
[http://dx.doi.org/10.1038/nrc3397] [PMID: 23151603]
[28]
Ramos S. Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways. Mol Nutr Food Res 2008; 52(5): 507-26.
[http://dx.doi.org/10.1002/mnfr.200700326] [PMID: 18435439]
[29]
Huang W-Y, Cai Y-Z, Zhang Y. Natural phenolic compounds from medicinal herbs and dietary plants: potential use for cancer prevention. Nutr Cancer 2010; 62(1): 1-20.
[http://dx.doi.org/10.1080/01635580903191585] [PMID: 20043255]
[30]
Zanoli P, Avallone R, Baraldi M. Sedative and hypothermic effects induced by b-asarone, a main component of Acorus Calamus. Phytother Res 1998; 12: 114-6.
[http://dx.doi.org/10.1002/(SICI)1099-1573(1998)12:1+<S114::AID-PTR268>3.0.CO;2-E]
[31]
Zhao J, Kobori N, Aronowski J, Dash PK. Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents. Neurosci Lett 2006; 393(2-3): 108-12.
[http://dx.doi.org/10.1016/j.neulet.2005.09.065] [PMID: 16233958]
[32]
Han JM, Lee YJ, Lee SY, et al. Protective effect of sulforaphane against dopaminergic cell death. J Pharmacol Exp Ther 2007; 321(1): 249-56.
[http://dx.doi.org/10.1124/jpet.106.110866] [PMID: 17259450]
[33]
Nalini K, Aroor A, Karanth K, Rao A. Centellaasiatica fresh leaf aqueous extract on learning and memory and biogenic amine turnover in albino rats. Fitoterapia 1992; 63: 232-7.
[34]
Kumar V. Potential medicinal plants for CNS disorders: an overview. Phytother Res 2006; 20(12): 1023-35.
[http://dx.doi.org/10.1002/ptr.1970] [PMID: 16909441]
[35]
Selvam AB. Inventory of Vegetable Crude Drug samples housed in Botanical Survey of India, Howrah. Pharmacogn Rev 2008; 2: 61-94.
[36]
Zhou M, Xing Y, Li W, Li X, Zhang X, Du X. Thioether-bridged mesoporous organosilica nanocapsules with weak acid-triggered charge reversal for drug delivery. Microporous Mesoporous Mater 2020; 302: 110242.
[http://dx.doi.org/10.1016/j.micromeso.2020.110242]
[37]
Ramírez de Molina A, Vargas T, Molina S, et al. The ellagic acid derivative 4,4′-di-O-methylellagic acid efficiently inhibits colon cancer cell growth through a mechanism involving WNT16. J Pharmacol Exp Ther 2015; 353(2): 433-44.
[http://dx.doi.org/10.1124/jpet.114.221796] [PMID: 25758919]
[38]
Oslo University Hospital and University of Oslo. Dietary Intervention in Follicular Lymphoma (KLYMF), NCT00455416 2008.
[39]
Falsaperla M, Morgia G, Tartarone A, Ardito R, Romano G. Support ellagic acid therapy in patients with hormone refractory prostate cancer (HRPC) on standard chemotherapy using vinorelbine and estramustine phosphate. Eur Urol 2005; 47(4): 449-54.
[http://dx.doi.org/10.1016/j.eururo.2004.12.001] [PMID: 15774240]
[40]
Hoffmann J, Junker H, Schmieder A, et al. EGCG downregulates IL-1RI expression and suppresses IL-1-induced tumorigenic factors in human pancreatic adenocarcinoma cells. Biochem Pharmacol 2011; 82(9): 1153-62.
[http://dx.doi.org/10.1016/j.bcp.2011.07.063] [PMID: 21787753]
[41]
Bettuzzi S. BrausiM,RizziF,Castagnetti G, Peracchia G, and Corti A. Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with highgrade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res 2006; 66(2): 1234-40.
[http://dx.doi.org/10.1158/0008-5472.CAN-05-1145] [PMID: 16424063]
[42]
Nakamura Y, Yogosawa S, Izutani Y, Watanabe H, Otsuji E, Sakai T. A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy. Mol Cancer 2009; 8(100): 100.
[http://dx.doi.org/10.1186/1476-4598-8-100] [PMID: 19909554]
[43]
Northwestern University and National Cancer Institute. Genistein in Treating Patients With Prostate Cancer, NCT01126879 2015.
[44]
Shao Z-M, Wu J, Shen Z-Z, Barsky S-H. Genistein exerts multiple suppressive effects on human breast carcinoma cells. Cancer Res 1998; 58(21): 4851-7.
[PMID: 9809990]
[45]
Park S-H, Park HS, Lee JH, et al. Induction of endoplasmic reticulum stress-mediated apoptosis and non-canonical autophagy by luteolin in NCI-H460 lung carcinoma cells. Food Chem Toxicol 2013; 56: 100-9.
[http://dx.doi.org/10.1016/j.fct.2013.02.022] [PMID: 23454208]
[46]
Yoo DR, Jang YH, Jeon YK, et al. Proteomic identification of anti-cancer proteins in luteolin-treated human hepatoma Huh-7 cells. Cancer Lett 2009; 282(1): 48-54.
[PMID: 19342156]
[47]
Tehran University of Medical Sciences, Evaluation of Effects of Silymarin on Cisplatin Induced Nephrotoxicity in Upper Gastrointestinal Adenocarcinoma, NCT01829178. 2025.
[48]
Herbert Irving Comprehensive Cancer Center and National Cancer Institute. 2013.
[49]
Kalemba D, Kunicka A. Antibacterial and antifungal properties of essential oils. Curr Med Chem 2003; 10(10): 813-29.
[PMID: 12678685]
[50]
Kim H-S. Do not put too much value on conventional medicines. J Ethnopharmacol 2005; 100(1-2): 37-9.
[PMID: 16039812]
[51]
Kosek M, Bern C, Guerrant RL. The global burden of diarrhoeal disease, as estimated from studies published between 1992 and 2000. Bull World Health Organ 2003; 81(3): 197-204.
[PMID: 12764516]
[52]
Kuge T, Shibata T, Willett MS. Multiple-dose escalation, safety, and tolerability study of wood creosote, the principal active ingredient of seirogan, an herbal antidiarrheal medication, in healthy subjects. J Clin Pharmacol 2003; 43(3): 284-90.
[http://dx.doi.org/10.1177/0091270002250606] [PMID: 12638397]
[53]
Joshi B, Sah GP, Basnet BB, Bhatt MR, Sharma D. Phytochemical extraction and antimicrobial properties of different medicinal plants: Ocimum sanctum (Tulsi), Eugenia caryophyllata (Clove), Achyranthesbidentata (Datiwan) and Azadirachtaindica (Neem). J Microbiol Antimicrob 2011; 3: 1-7.
[54]
Aqil F, Ahmad I, Zafar M. Antioxidant and free radical scavenging properties of twelve traditionally used Indian medicinal plants. Turk J Biol 2006; 30: 177-83.
[55]
Heinrich M. Ethnobotany and its role in drug development. Phytother Res 2000; 14(7): 479-88.
[http://dx.doi.org/10.1002/1099-1573(200011)14:7<479::AID-PTR958>3.0.CO;2-2] [PMID: 11054835]
[56]
Krishnaiah D, Sarbatly R, Nithyanandam R. A review of the antioxidant potential of medicinal plant Species. Food Bioprod Process 2011; 89: 217-33.
[http://dx.doi.org/10.1016/j.fbp.2010.04.008]
[57]
Garg V, Dhar VJ, Sharma A, Dutt R. Facts about standardization of herbal medicine: a review. J chineseIntegrMedi 2012; 10: 1077-83.
[58]
Awoyemi OK, Ewa EE, Abdulkarim IA, Aduloju AR. Ethnobotanical assessment of herbal plants in southwestern Nigeria. Acad Res Int 2012; 2: 50-7.
[59]
Liu Z, Liu Y, Chao Z, Song Z, Wang C, Lu A. In vitro antioxidant activities of maillard reaction products produced in the steaming process of Polygonum multiflorum root. Nat Prod Commun 2011; 6(1): 55-8.
[http://dx.doi.org/10.1177/1934578X1100600114] [PMID: 21366046]
[60]
Zhang S, Liu X, Zhang ZL, He L, Wang Z, Wang GS. Isolation and identification of the phenolic compounds from the roots of Sanguisorba officinalis L. and their antioxidant activities. Molecules 2012; 17(12): 13917-22.
[http://dx.doi.org/10.3390/molecules171213917] [PMID: 23178307]
[61]
Wang BQ. Salvia miltiorrhiza : chemical and pharmacological review of a medicinal plant. J Med Plants Res 2010; 4: 2813-20.
[62]
Zhang YH, Liu JT, Wen BY, Liu N. Mechanisms of inhibiting proliferation of vascular smooth muscle cells by serum of rats treated with Dahuang Zhechong pill. J Ethnopharmacol 2009; 124(1): 125-9.
[http://dx.doi.org/10.1016/j.jep.2009.04.012] [PMID: 19527826]
[63]
Li ZY, Zhi HJ, Zhang FS, et al. Metabolomic profiling of the antitussive and expectorant plant Tussilago farfara L. by nuclear magnetic resonance spectroscopy and multivariate data analysis. J Pharm Biomed Anal 2013; 75: 158-64.
[http://dx.doi.org/10.1016/j.jpba.2012.11.023] [PMID: 23261808]
[64]
Rahman S, Cao S, Steadman KJ, Wei M, Parekh HS. Native and β-cyclodextrin-enclosed curcumin: entrapment within liposomes and their in vitro cytotoxicity in lung and colon cancer. Drug Deliv 2012; 19(7): 346-53.
[http://dx.doi.org/10.3109/10717544.2012.721143] [PMID: 23030405]
[65]
Lin Y-L, Liu Y-K, Tsai N-M, et al. A Lipo-PEG-PEI complex for encapsulating curcumin that enhances its antitumor effects on curcumin-sensitive and curcumin-resistance cells. Nanomedicine (Lond) 2012; 8(3): 318-27.
[http://dx.doi.org/10.1016/j.nano.2011.06.011] [PMID: 21704596]
[66]
Moghimi HR, Shirazi FH. ShafieeArdestani M, Oghabian MA, Saffari M, Sojoudi J. In Vitro and In Vivo Enhancement of Antitumoral Activity of Liposomal Antisense Oligonucleotides by Cineole as a Chemical Penetration Enhancer. J Nanomater 2015; 2015: 1-10.
[http://dx.doi.org/10.1155/2015/967473]
[67]
Jiang QQ, Fan LY, Yang GL, et al. Improved therapeutic effectiveness by combining liposomal honokiol with cisplatin in lung cancer model. BMC Cancer 2008; 8(1): 242.
[PMID: 18706101]
[68]
Yang HY, Li Y, Lee DS. Recent Advances of pH-Induced Charge-Convertible Polymer-Mediated Inorganic Nanoparticles for Biomedical Applications. Macromol Rapid Commun 2020; 9: e2000106.
[http://dx.doi.org/10.1002/marc.202000106] [PMID: 32374479]
[69]
Wang F, Chen J, Dai W, He Z, Zhai D, Chen W. Pharmacokinetic studies and anticancer activity of curcumin-loaded nanostructured lipid carriers. Acta Pharm 2017; 67(3): 357-71.
[http://dx.doi.org/10.1515/acph-2017-0021] [PMID: 28858837]
[70]
Majumdar D, Jung K-H, Zhang H, et al. Luteolin nanoparticle in chemoprevention: in vitro and in vivo anticancer activity. Cancer Prev Res (Phila) 2014; 7(1): 65-73.
[http://dx.doi.org/10.1158/1940-6207.CAPR-13-0230] [PMID: 24403290]
[71]
Das J, Das S, Samadder A, Bhadra K, Khuda-Bukhsh AR. Poly (lactide-co-glycolide) encapsulated extract of Phytolacca decandra demonstrates better intervention against induced lung adenocarcinoma in mice and on A549 cells. Eur J Pharm Sci 2012; 47(2): 313-24.
[http://dx.doi.org/10.1016/j.ejps.2012.06.018] [PMID: 22771545]
[72]
Valodkar M, Jadeja RN, Thounaojam MC, Devkar RV, Thakore S. In vitro toxicity study of plant latex capped silver NPs in human lung carcinoma cells. Mater Sci Eng C 2011; 31(8): 1723-8.
[http://dx.doi.org/10.1016/j.msec.2011.08.001]
[73]
Wang C, Mathiyalagan R, Kim YJ, et al. Rapid green synthesis of silver and gold nanoparticles using Dendropanax morbifera leaf extract and their anticancer activities. Int J Nanomedicine 2016; 11: 3691-701.
[http://dx.doi.org/10.2147/IJN.S97181] [PMID: 27570451]
[74]
Anand K, Gengan RM, Phulukdaree A, Chuturgoon A. Agroforestry waste Moringa oleifera petals mediated green synthesis of gold NPs and their anticancer and catalytic activity. J Ind Eng Chem 2015; 21: 1105-11.
[http://dx.doi.org/10.1016/j.jiec.2014.05.021]
[75]
Singh P, Singh H, Ahn S, et al. Pharmacological importance, characterization and applications of gold and silver nanoparticles synthesized by Panax ginseng fresh leaves. Artif Cells Nanomed Biotechnol 2017; 45(7): 1415-24.
[http://dx.doi.org/10.1080/21691401.2016.1243547] [PMID: 27855495]
[76]
Sankar R, Maheswari R, Karthik S, Shivashangari KS, Ravikumar V. Anticancer activity of Ficus religiosa engineered copper oxide nanoparticles. Mater Sci Eng C 2014; 44: 234-9.
[http://dx.doi.org/10.1016/j.msec.2014.08.030] [PMID: 25280701]
[77]
Fong WK, Negrini R, Vallooran JJ, Mezzenga R, Boyd BJ. Responsive self-assembled nanostructured lipid systems for drug delivery and diagnostics. J Colloid Interface Sci 2016; 484: 320-39.
[http://dx.doi.org/10.1016/j.jcis.2016.08.077] [PMID: 27623190]
[78]
Lyon PC, Griffiths LF, Lee J, et al. Clinical trial protocol for TARDOX: a phase I study to investigate the feasibility of targeted release of lyso-thermosensitive liposomal doxorubicin (ThermoDox®) using focused ultrasound in patients with liver tumours. J Ther Ultrasound 2017; 5: 28.
[http://dx.doi.org/10.1186/s40349-017-0104-0] [PMID: 29118984]
[79]
Paolino D, Cosco D, Gaspari M, Celano M, Wolfram J, Voce P. Targeting the thyroid gland with thyroid- stimulating hormone (TSH)-- nanoliposomes. Biomaterials 2014; 35: 7101-9.
[http://dx.doi.org/10.1016/j.biomaterials.2014.04.088] [PMID: 24836306]
[80]
Silva P, Bonifácio B, Ramos M, Negri K, Maria Bauab T, Chorilli M. Nanotechnology-based drug delivery systems and herbal medicines: a review. Int J Nanomedicine 2014; 9: 1-15.
[81]
Caldeira de Araújo Lopes S, Vinícius Melo Novais M, Salviano Teixeira C, et al. Preparation, physicochemical characterization, and cell viability evaluation of long-circulating and pH-sensitive liposomes containing ursolic acid. BioMed Res Int 2013; 2013: 467147.
[http://dx.doi.org/10.1155/2013/467147] [PMID: 23984367]
[82]
Wang W, Zhang L, Le Y, Chen JF, Wang J, Yun J. Synergistic effect of PEGylated resveratrol on delivery of anticancer drugs. Int J Pharm 2016; 498(1-2): 134-41.
[http://dx.doi.org/10.1016/j.ijpharm.2015.12.016] [PMID: 26685725]
[83]
Sailor G, Seth A, Parmar G, Chauhan S, Javia A. Formulation andin vitro evaluation of berberine-containingliposome optimised by 32 full factorial designs. J Appl Pharm Sci 2015; 5: 23-8.
[http://dx.doi.org/10.7324/JAPS.2015.50704]
[84]
Odeh F, Ismail SI, Abu-Dahab R, Mahmoud IS, Al Bawab A. Thymoquinone in liposomes: a study of loading efficiency and biological activity towards breast cancer. Drug Deliv 2012; 19(8): 371-7.
[http://dx.doi.org/10.3109/10717544.2012.727500] [PMID: 23043626]
[85]
Nguyen TX, Huang L, Liu L, Elamin Abdalla AM, Gauthier M, Yang G. Chitosan-coated nano-liposomes for the oral delivery of berberine hydrochloride. J Mater Chem B Mater Biol Med 2014; 2(41): 7149-59.
[http://dx.doi.org/10.1039/C4TB00876F] [PMID: 32261793]
[86]
Saengkrit N, Saesoo S, Srinuanchai W, Phunpee S. Ruktanonchai UInfluence of curcumin loaded cationic liposome on anticancer activity forcervical can certherapy. Colloids Surf B 2014; 114: 349-56.
[87]
Forgiarini A, Esquena J, González C, Solans C. Formation of nano-emulsions by low-energy emulsification methods at constant temperature. Langmuir 2001; 17: 2076-83.
[http://dx.doi.org/10.1021/la001362n]
[88]
Djordjevic D, Kim HJ, McClements DJ, Decker EA. Physical Stability of Whey Protein-stabilized Oil-in-water Emulsions at pH 3: Potential ω-3 Fatty Acid Delivery Systems (Part A). J Food Sci 2004; 69: C351-5.
[http://dx.doi.org/10.1111/j.1365-2621.2004.tb10696.x]
[89]
Ahmed K, Li Y, McClements DJ, Xiao H. Nanoemulsion- and emulsion-based delivery systems for curcumin: Encapsulation and release properties. Food Chem 2012; 132: 799-807.
[http://dx.doi.org/10.1016/j.foodchem.2011.11.039]
[90]
Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 2006; 5(6): 493-506.
[http://dx.doi.org/10.1038/nrd2060] [PMID: 16732220]
[91]
Gisbert-Garzarán M, Vallet-Regí M. Influence of the surface functionalization on the fate and performance of mesoporous silica nanoparticles. Nanomaterials (Basel) 2020; 10(5): 16.
[http://dx.doi.org/10.3390/nano10050916] [PMID: 32397449]
[92]
Mizrahi M, Friedman-Levi Y, Larush L, et al. Pomegranate seed oil nanoemulsions for the prevention and treatment of neurodegenerative diseases: the case of genetic CJD. Nanomedicine (Lond) 2014; 10(6): 1353-63.
[http://dx.doi.org/10.1016/j.nano.2014.03.015] [PMID: 24704590]
[93]
Mehnert W, Mäder K. Solid lipid nanoparticles: production, characterization and applications. Adv Drug Deliv Rev 2001; 47(2-3): 165-96.
[http://dx.doi.org/10.1016/S0169-409X(01)00105-3] [PMID: 11311991]
[94]
Martins S, Sarmento B, Ferreira DC, Souto EB. Lipid-based colloidal carriers for peptide and protein delivery--liposomes versus lipid nanoparticles. Int J Nanomedicine 2007; 2(4): 595-607.
[PMID: 18203427]
[95]
Hu H, Liu D, Zhao X, Qiao M, Chen D. Preparation, characterization, cellular uptake and evaluation in vivo of solid lipid nanoparticles loaded with cucurbitacin B. Drug Dev Ind Pharm 2013; 39(5): 770-9.
[http://dx.doi.org/10.3109/03639045.2012.702348] [PMID: 22794139]
[96]
Zhu RR, Qin LL, Wang M, et al. Preparation, characterization, and anti-tumor property of podophyllotoxin-loaded solid lipid nanoparticles. Nanotechnology 2009; 20(5): 055702.
[http://dx.doi.org/10.1088/0957-4484/20/5/055702] [PMID: 19417361]
[97]
Madan J, Pandey RS, Jain V, Katare OP, Chandra R, Katyal A. Poly (ethylene)-glycol conjugated solid lipid nanoparticles of noscapine improve biological half-life, brain delivery and efficacy in glioblastoma cells. Nanomedicine (Lond) 2013; 9(4): 492-503.
[http://dx.doi.org/10.1016/j.nano.2012.10.003] [PMID: 23117045]
[98]
Wang L, Li H, Wang S, et al. Enhancing the antitumor activity of berberine hydrochloride by solid lipid nanoparticle encapsulation. AAPS PharmSciTech 2014; 15(4): 834-44.
[http://dx.doi.org/10.1208/s12249-014-0112-0] [PMID: 24696391]
[99]
Chen R, Wang S, Zhang J, Chen M, Wang Y. Aloe-emodin loaded solid lipid nanoparticles: formulation design and in vitro anti-cancer study. Drug Deliv 2015; 22(5): 666-74.
[http://dx.doi.org/10.3109/10717544.2014.882446] [PMID: 24512431]
[100]
Rizwanullah M, Amin S, Ahmad J. Improved pharmacokinetics and antihyperlipidemic efficacy of rosuvastatin-loaded nanostructured lipid carriers. J Drug Target 2017; 25(1): 58-74.
[http://dx.doi.org/10.1080/1061186X.2016.1191080] [PMID: 27186665]
[101]
Rizwanullah M, Ahmad J, Amin S. Nanostructured lipid carriers: a novel platform for chemotherapeutics. Curr Drug Deliv 2016; 13(1): 4-26.
[http://dx.doi.org/10.2174/1567201812666150817124133] [PMID: 26279117]
[102]
Lin M, Teng L, Wang Y, Zhang J, Sun X. Curcumin-guided nanotherapy: a lipid-based nanomedicine for targeted drug delivery in breast cancer therapy. Drug Deliv 2016; 23(4): 1420-5.
[http://dx.doi.org/10.3109/10717544.2015.1066902] [PMID: 26203688]
[103]
Jyoti K, Kaur K, Pandey RS, Jain UK, Chandra R, Madan J. Inhalable nanostructured lipid particles of 9-bromo-noscapine, a tubulin-binding cytotoxic agent: in vitro and in vivo studies. J Colloid Interface Sci 2015; 445: 219-30.
[http://dx.doi.org/10.1016/j.jcis.2014.12.092] [PMID: 25622047]
[104]
Ng WK, Saiful Yazan L, Yap LH, Wan Nor Hafiza WA, How CW, Abdullah R. Thymoquinone-loaded nanostructured lipid carrier exhibited cytotoxicity towards breast cancer cell lines (MDA-MB-231 and MCF-7) and cervical cancer cell lines (HeLa and SiHa). BioMed Res Int 2015; 2015: 263131.
[http://dx.doi.org/10.1155/2015/263131] [PMID: 25632388]
[105]
Zhang XY, Qiao H, Ni JM, Shi YB, Qiang Y. Preparation of isoliquiritigenin-loaded nanostructured lipid carrier and the in vivo evaluation in tumor-bearing mice. Eur J Pharm Sci 2013; 49(3): 411-22.
[http://dx.doi.org/10.1016/j.ejps.2013.04.020] [PMID: 23624327]
[106]
Carbone C, Campisi A, Musumeci T, Raciti G, Bonfanti R, Puglisi G. FA-loaded lipid drug delivery systems: preparation, characterization and biological studies. Eur J Pharm Sci 2014; 52: 12-20.
[http://dx.doi.org/10.1016/j.ejps.2013.10.003] [PMID: 24514450]
[107]
Rahman HS, Rasedee A, Yeap SK, et al. Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trials. BioMed Res Int 2014; 2014: 920742.
[http://dx.doi.org/10.1155/2014/920742] [PMID: 25025076]
[108]
Rahman HS, Rasedee A, How CW, et al. Zerumbone-loaded nanostructured lipid carriers: preparation, characterization, and antileukemic effect. Int J Nanomedicine 2013; 8: 2769-81.
[http://dx.doi.org/10.2147/IJN.S45313] [PMID: 23946649]
[109]
Govender R, Phulukdaree A, Gengan RM, Anand K, Chuturgoon AA. Silver nanoparticles of Albizia adianthifolia: the induction of apoptosis in human lung carcinoma cell line. J Nanobiotechnology 2013; 11(1): 5.
[http://dx.doi.org/10.1186/1477-3155-11-5] [PMID: 23418790]
[110]
Rizwan SB, Assmus D, Boehnke A, et al. Preparation of phytantriol cubosomes by solvent precursor dilution for the delivery of protein vaccines. Eur J Pharm Biopharm 2011; 79(1): 15-22.
[http://dx.doi.org/10.1016/j.ejpb.2010.12.034] [PMID: 21237267]
[111]
Rossetti FC, Depieri LV, Praça FG, et al. Optimization of protoporphyrin IX skin delivery for topical photodynamic therapy: Nanodispersions of liquid-crystalline phase as nanocarriers. Eur J Pharm Sci 2016; 83: 99-108.
[http://dx.doi.org/10.1016/j.ejps.2015.12.003] [PMID: 26657201]
[112]
Pangeni R, Sharma S, Mustafa G, Ali J, Baboota S. Vitamin E loaded resveratrol nanoemulsion for brain targeting for the treatment of Parkinson’s disease by reducing oxidative stress. Nanotechnology 2014; 25(48): 485102.
[http://dx.doi.org/10.1088/0957-4484/25/48/485102] [PMID: 25392203]
[113]
Esposito E, Ravani L, Mariani P, et al. Curcumin containing monoolein aqueous dispersions: a preformulative study. Mater Sci Eng C 2013; 33(8): 4923-34.
[http://dx.doi.org/10.1016/j.msec.2013.08.017] [PMID: 24094206]
[114]
Murgia S, Sara B, Angela M. et al. Drug-Loaded Fluorescent Cubosomes: Versatile Nanoparticles forPotential Theranostic Applications. Langmuir 2013.
[115]
Wang M, Li L, Zhang X, et al. Magnetic resveratrol liposomes as a new theranostic platform for magnetic resonance imaging guided Parkinson’s disease targeting therapy. ACS Sustain Chem& Eng 2017.
[116]
Ganta S, Singh A, Rawal Y, et al. Formulation development of a novel targetedtheranosticnanoemulsion of docetaxel toovercome multidrug resistance in ovarian cancer. Drug Deliv 2016; 23(3): 958-70.
[http://dx.doi.org/10.3109/10717544.2014.923068] [PMID: 24901206]
[117]
Ucar E, Teksoz S, Icvhedef C, et al. SerapTeksoz, CigdemIchedef, Ayfer Yurt Kilcar, E.IlkerMedine, Kadir Ari, Yasemin Parlak, B. Elvan SayitBilgin, PerihanUnak. Synthesis, characterization and radiolabeling of folic acid modified nanostructured lipid carriers as a contrast agent and drug delivery system. Appl Radiat Isot 2016.

Rights & Permissions Print Cite
Article Metrics
28
Wayfinder Image
Open Access Journals Promotions
© 2024 Bentham Science Publishers | Privacy Policy