Title:Human Exfoliated Deciduous Teeth Stem Cells: Features and Therapeutic Effects on Neurogenerative and Hepatobiliary-pancreatic Diseases
Volume: 16
Issue: 5
Author(s): Nurul W.A. Wahab, Rhanye M. Guad, Vetriselvan Subramaniyan, Ismail M. Fareez, Ker W. Choy, Srinivasa R. Bonam, Chandrasekaran Selvaraju, Maw S. Sim, Subash C.B. Gopinath*Yuan S. Wu*
Affiliation:
- School of Bioprocess Engineering, Universiti Malaysia Perlis, Arau 02600, Perlis,Malaysia
- Department of Biochemistry, School of Medicine, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Selangor 42610,Malaysia
Keywords:
Totipotency, pluripotent, human exfoliated deciduous teeth, SHEDs, neurodegenerative disease, retinal degeneration,
liver diseases, diabetes mellitus, organ transplantation.
Abstract: Stem cells can multiply into more cells with similar types in an undifferentiated form
and differentiate into other types of cells. The great success and key essence of stem cell technology
is the isolation of high-quality Mesenchymal Stem Cells (MSCs) with high potency, either with
multipotent or pluripotent property. In this line, Stem cells from Human Exfoliated Deciduous
teeth (SHEDs) are highly proliferative stem cells from dental pulp and have multipoint differentiation
capacity. These cells play a pivotal role in regenerative medicine, such as cell repair associated
with neurodegenerative, hepatobiliary, and pancreatic diseases. In addition, stem cell therapy has
been widely used to regulate immune response and repair of tissue lesions. This overview captured
the differential biological characteristics, and the potential role of stem cell technology and paid
special attention to human welfare SHEDs in eliminating the above-mentioned diseases. This review
provides further insights into stem cell technology by expanding the therapeutic potential of
SHEDs in tissue engineering and cell organ repairs.
