Title:CircRNAs in Lung-intestinal Axis Cancer
Volume: 21
Issue: 4
Author(s): Chengmin Wang, Yuan Feng, Bingxin Li, Di Zhou, Jingjing Ma, Gang Chen*Ning Li*
Affiliation:
- School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016,China
- School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016,China
Keywords:
CircRNAs, lung-intestinal axis, MiRNA, differential expression, lung-intestinal exterior-interior
relationship, biomarker.
Abstract: The “exterior-interior relationship between the lung and the large intestine” is
a basic theory in Traditional Chinese Medicine (TCM), which has been confirmed by
mounting evidence, and the lung-intestinal axis can be seen as an extension of this
theory. Circular RNAs (circRNAs) are a kind of conserved and structurally stable noncoding
RNAs, which have been found to be differentially expressed and associated with
the development of cancer in malignant tumors. Many studies have found that circRNAs
play an important role in lung and intestinal cancers. This review focuses on circRNAs
and reveals that there are common circRNAs that are both highly or poorly expressed in
lung-intestinal axis cancers and most of them regulate the proliferation, migration, and
invasion of cancer cells by sponging miRNAs. These results not only provide new
evidence and research ideas for the “exterior-interior relationship between the lung and
the large intestine”, but also suggest that circRNAs can be new potential therapeutic
targets for the future drug research of lung-intestinal axis diseases.
