Title:Nanotherapeutics in Neuropathologies: Obstacles, Challenges and Recent Advancements in CNS Targeted Drug Delivery Systems
Volume: 19
Issue: 5
Author(s): Vimal Patel, Vishal Chavda and Jigar Shah*
Affiliation:
- Department of Pharmaceutics, Institute of Pharmacy, Nirma University, Ahmedabad,India
Keywords:
Brain barriers, brain tumour barriers, neuropathology, neuro-nano therapeutics, nanocarriers, blood brain barrier.
Abstract: Neurology and associated nanotherapeutics are a complex field in terms of therapeutics
and neurological disorder complexity. The brain is an intricate appendage and requires more precise
embattled treatment for the particular diseases and hence it is a broad scale for developing
more targeted drug deliveries. The brain is one of the most inaccessible tissues of the body due to
the existence of the blood-brain barrier (BBB), thus delivery of drugs inside the brain is a striking
dare and it is also tricky to treat central nervous system (CNS) complications pharmacologically.
The therapeutic aspiration is to accomplish the lowest drug meditation in the brain tissues so as to
gain favoured therapeutic results. To devastate this obstacle, nanotechnology is engaged in the
field of targeted brain drug delivery and neuropathology targeting. These carriers hold myriad abilities
as they may augment the drug delivery into the brain by shielding them from degradation and
prolonging their transmission in the blood, as well as promoting their transport through the BBB.
Nanopharmaceuticals are quickly sprouting as a new avenue that is engaged with the drug-loaded
nanocarriers to demonstrate unique physicochemical properties and tiny size range for penetrating
the central nervous system. The enchantment behind their therapeutic achievement is the condensed
drug dose and inferior toxicity, whereby restricting the therapeutic compound to the specific
site. Therefore, in this article, we have tried to recapitulate the advances of the novel scopes for
the brain targeted drug delivery for complex neurological disorders.
