Title:The Potential Application of Novel Drug Delivery Systems for Phytopharmaceuticals and Natural Extracts – Current Status and Future Perspectives
Volume: 21
Issue: 18
Author(s): Mohamad Fawzi Mahomoodally*, Nabeelah Sadeer , Mehtaab Edoo and Katharigatta N. Venugopala
Affiliation:
- Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City,Vietnam
Keywords:
Nanoparticles, novel drug delivery system, phytoconstituents, phytosomes, emulsion, ethosome, herbal drugs, liposome,
microsphere.
Abstract: Phytocompounds isolated from plants are well appraised for their broad pharmacological
propensities in several pathologies. One key benefit of phytoconstituents is their relatively low toxicity
and adverse effects. Nonetheless, poor solubility, permeation, and poor specificity at the target site
tend to hinder its therapeutic efficacy. Hence, novel technologies for drug delivery systems are being
developed via the use of various nanoformulation strategies to overcome these challenges and give uniform
medication focusing at the dynamic site in desired concentration and improved therapeutic efficacy.
Such approaches comprise of novel drug delivery systems (NDDS). The utilisation of herbal
formulations for NDDS is more beneficial and advantageous as opposed to others. The utilisation of
ethosome, liposome, emulsion, phytosomes, microsphere, and strong lipid nanoparticles of herbal formulation
has improved the remedial impacts of plant extricates. With the utilisation of all these, directed
delivery of the formulation is accomplished, because of which the formulation exhibits impact
on the site, and its’ bioavailability is, likewise, expanded. With these novel medication conveyance
frameworks, the actives and concentrates, which are utilised as part of natural formulations, exhibit a
sustained release, enhancement in stability, improved therapeutic efficacy, and protection from toxicity.
The primary motivation behind creating alternative drug delivery technologies is to expand the
effectiveness of drug conveyance and safety in the process and give more comfort to the patient. In this
review, the importance of various phytocompounds in the delivery of drugs is highlighted as well as
their importance in reducing the risk or diseases.
