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Combinatorial Chemistry & High Throughput Screening

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ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

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Perspective Article

Could Targeting HMGB1 be Useful for the Clinical Management of COVID-19 Infection?

Author(s): Mustafa Çelebier and İbrahim Celalettin Haznedaroğlu*

Volume 24, Issue 4, 2021

Published on: 28 July, 2020

Page: [587 - 590] Pages: 4

DOI: 10.2174/1386207323999200728114927

Abstract

Since the high mobility group box-1 (HMGB1) molecule had been recognized as a proinflammatory cytokine, which mediates endotoxin lethality of mice, there have been lots of papers about targeting the HMGB1 within the contexts of infection, inflammation, and cancer. The pathogenic impact of HMGB1 to the severe acute respiratory syndrome (SARS) and disease management with herbal formulations targeting this unique protein have already been proposed. However, the failure of the numerous current anti-viral therapies on the ongoing viral infections casts reappraisal of the possible interrelationships regarding the HMGB1 and SARS-CoV-2. COVID-19 pandemic due to the SARS-CoV-2 virus is a currently ongoing challenging global health crisis. There is still not any proven exact treatment of COVID-19 with high level of evidence. In this paper, we focused on the potential usage of external and/or inhalation preparation of antiviral/antibacterial herbal products capable of targeting HMGB1 for the clinical management candidates of the ongoing COVID-19 infection.

Keywords: High mobility group box-1 (HMGB1), COVID-19, infection, drug repurposing, herbal medicinal products, clinical trial.

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