Title:Fibrosis and Regulation of Nerve Regeneration in the Peripheral and Central Nervous Systems
Volume: 19
Issue: 8
Author(s): Nilabh Ghosh, Daniel Kalbermatten, Srinivas Madduri and Raphael Guzman*
Affiliation:
- Department of Biomedicine, University Hospital Basel, Basel,Switzerland
Keywords:
Fibrosis, nerve regeneration, peripheral nervous system, central nervous system, nerve injury macrophages, injuryinduced
scarring.
Abstract: The concepts of the neurobiology of nerve injury, fibrosis and regeneration are critical. Millions
of people worldwide are affected every year by traumatic and non-traumatic forms of injury to
the spinal cord or the peripheral nerves that cause huge socioeconomic burdens. Innumerable studies
over the last few decades have studied the disease pathogenesis. Also, several strategies and techniques
have undertaken to repair injuries in the PNS and CNS, but all have resulted in suboptimal
functional outcomes. In this review, we have provided a general description of injury-induced scarring
and fibrosis in the PNS and CNS. We also discuss the important signaling factors and mechanistic
pathways that regulate the disease pathogenesis. We further discuss the current paradigms that suggest
the involvement of essential factors in and during disease progression. We believe that readers and researchers
will gain key insights into how fibrosis regulates the regenerative process in the PNS and
CNS. We hope this review will help clinicians and scientists to address an unmet medical need and direct
further studies towards the identification of better therapeutic approaches.
