Title:Transplantation of Stem Cells as a Potential Therapeutic Strategy in Neurodegenerative Disorders
Volume: 16
Issue: 2
Author(s): Tahereh Ebrahimi, Mozhgan Abasi, Fatemeh Seifar, Shirin Eyvazi, Mohammas Saeid Hejazi, Vahideh Tarhriz*Soheila Montazersaheb*
Affiliation:
- Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz,Iran
- Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz,Iran
Keywords:
Stem cells, neurological disorders, injured brain, spinal cord, Huntington’s disease, pluripotent.
Abstract: Stem cells are considered to have significant capacity to differentiate into various cell types
in humans and animals. Unlike specialized cells, these cells can proliferate several times to produce
millions of cells. Nowadays, pluripotent stem cells are important candidates to provide a renewable
source for the replacement of cells in tissues of interest. The damage to neurons and glial cells in the
brain or spinal cord is present in neurological disorders such as Amyotrophic lateral sclerosis, stroke,
Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, Huntington’s disease, spinal cord injury,
lysosomal storage disorder, epilepsy, and glioblastoma. Therefore, stem cell transplantation can be
used as a novel therapeutic approach in cases of brain and spinal cord damage. Recently, researchers
have generated neuron-like cells and glial-like cells from embryonic stem cells, mesenchymal stem
cells, and neural stem cells. In addition, several experimental studies have been performed for developing
stem cell transplantation in brain tissue. Herein, we focus on stem cell therapy to regenerate injured
tissue resulting from neurological diseases and then discuss possible differentiation pathways of stem
cells to the renewal of neurons.
