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Review Article

Lipid Metabolism Genes in Stroke Pathogenesis: The Atherosclerosis

Author(s): Yit-Lai Chow, Lai Kuan Teh, Loh Huey Chyi, Li Fang Lim, Chin Chu Yee and Loo Keat Wei*

Volume 26, Issue 34, 2020

Page: [4261 - 4271] Pages: 11

DOI: 10.2174/1381612826666200614180958

Price: $65

Abstract

Stroke is the second leading cause of death and a major cause of disability worldwide. Both modifiable and non-modifiable risk factors can affect the occurrence of ischemic stroke at varying degrees. Among them, atherosclerosis has been well-recognized as one of the main culprits for the rising incidence of stroke-related mortality. Hence, the current review aimed to summarize the prominent role of lipid metabolism genes such as PCSK9, ApoB, ApoA5, ApoC3, ApoE, and ABCA1 in mediating ischemic stroke occurrence.

Keywords: Lipids, gene, stroke, metabolism, PCSK9, ApoB, ApoA5, ApoC3, ApoE, ABCA1.

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