Title:Sericin: A Versatile Protein Biopolymer with Therapeutic Significance
Volume: 26
Issue: 42
Author(s): Rasika Suryawanshi, Jovita Kanoujia, Poonam Parashar and Shubhini. A. Saraf*
Affiliation:
- Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University; (A Central University), VidyaVihar, Raebareli Road, Lucknow, U.P.,India
Keywords:
Sericin, silk nanoparticles, protein nanoparticles, Bombyx Mori, novel drug delivery, therapeutic.
Abstract: Sericin is a unique proteinaceous biopolymer obtained from cocoons of Bombyx Mori. It has become
very popular since it is bestowed with numerous health benefits. Sericin is composed of 18 types of amino acids,
out of which 8 amino acids play a significant role in human metabolic pathways. Sericin is easily amenable to
make into novel dosage forms and also has been conferred with numerous therapeutic activities such as wound
healing, antihypertensive, neuro-protective, antitumor, anti-diabetic, anti-wrinkle, anti-ageing and antioxidant
amongst various others. This review summarizes the current status of sericin, as a therapeutic moiety with a focus
on active constituents as well as their proposed mechanism in the treatment of various chronic diseases. It also
summarizes previous and current in-vitro, in-vivo, cell lines studies and clinical trials based pieces of evidence
corroborating the therapeutic activities of sericin.